{"id":"W2000493107","doi":"10.4161/cbt.9.9.11432","title":"MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and rapamycin sensitivity","year":2010,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Tamoxifen; Estrogen; Cancer research; Biology; Breast cancer; Estrogen receptor; Phenotype; Cell culture; Aromatase; Internal medicine; Cell growth; Aromatase inhibitor; Cancer; Endocrinology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793105,0.0004608231,0.0003990919,0.0005652956,0.0002524225,0.0002907759,0.0002371466,0.0002982592,0.001465816],"category_scores_gemma":[0.0001428463,0.0002343547,0.0004470051,0.000357505,0.0002016353,0.0001403431,0.0003380967,0.0006892554,0.001001718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115656,"about_ca_system_score_gemma":0.0001430718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206568,"about_ca_topic_score_gemma":0.002039487,"domain_scores_codex":[0.9997242,0.00003317777,0.00003205501,0.00003980399,0.0001157899,0.00005488337],"domain_scores_gemma":[0.9997967,0.00004786163,0.00003392503,0.00004284916,0.00003400426,0.00004468246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006014557,0.00004015789,0.0009996414,0.00001566041,0.000009264128,0.0001238024,0.00004191928,0.00002699359,0.9972796,0.00005366995,0.00007033493,0.001278663],"study_design_scores_gemma":[0.0000149894,0.001073315,0.03348503,0.00000970426,0.00004717485,0.001847233,0.0001730042,0.0007345258,0.9554072,0.00004905909,0.007141182,0.0000175755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909368,0.001195456,0.003375028,0.000132395,0.00003892216,0.00009271705,0.00108814,0.00009471648,0.003045897],"genre_scores_gemma":[0.9612589,0.001738018,0.01453386,0.000226713,0.00002250615,0.0001673001,0.007041824,0.00009348801,0.01491747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465816,"threshold_uncertainty_score":0.004903674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009096175471917847,"score_gpt":0.2498819291119252,"score_spread":0.2407857536400074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}