{"id":"W2000500389","doi":"10.2174/15672050113106660159","title":"Serum β-Amyloid Peptide Levels Spike in the Early Stage of Alzheimer- Like Plaque Pathology in an APP/PS1 Double Transgenic Mouse Model","year":2013,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Genetically modified mouse; Transgene; Presenilin; Alzheimer's disease; Pathology; Amyloid (mycology); Population; Immunohistochemistry; Biomarker; Amyloid precursor protein; Internal medicine; Endocrinology; Medicine; Biology; Disease; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001845641,0.0006898373,0.0004756629,0.0006164717,0.0001858403,0.0004226928,0.0001831092,0.0006405386,0.001584088],"category_scores_gemma":[0.0001677621,0.000312877,0.0003078816,0.0002657581,0.0002771275,0.0004875061,0.0001681343,0.001070318,0.000630045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363748,"about_ca_system_score_gemma":0.0001095386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000377295,"about_ca_topic_score_gemma":0.0004630926,"domain_scores_codex":[0.9998386,0.00001141866,0.00001808471,0.00005116634,0.00004726629,0.00003338446],"domain_scores_gemma":[0.9997758,0.00001301428,0.0001050939,0.00001600498,0.00003596979,0.00005410159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006408324,0.0001567028,0.001762287,0.00004667117,0.00001244901,0.0002980235,0.00003877036,0.0000243094,0.994092,0.00004560578,0.0001381269,0.002744135],"study_design_scores_gemma":[0.00009268257,0.003430148,0.07955695,0.00003580363,0.0001263432,0.003185386,0.0001325351,0.001422202,0.9071674,0.0003851984,0.004428721,0.00003664462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915522,0.002177265,0.002943859,0.0002212259,0.00006557947,0.00004436423,0.0008770028,0.0002570564,0.001861471],"genre_scores_gemma":[0.9798682,0.002046247,0.00493917,0.000339826,0.00005445103,0.0001868233,0.001359797,0.00007550028,0.01112995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001584088,"threshold_uncertainty_score":0.00529927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2943725841191152,"score_gpt":0.4454730562496877,"score_spread":0.1511004721305725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}