{"id":"W2000529567","doi":"10.1071/ch06319","title":"Synthesis of a Reversible Streptavidin Binder for Biomimetic Assemblies","year":2007,"lang":"en","type":"article","venue":"Australian Journal of Chemistry","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Streptavidin; Chemistry; Biotin; Supramolecular chemistry; Biotinylation; Biocatalysis; Benzoic acid; Dissociation constant; Dissociation (chemistry); Combinatorial chemistry; Crystallography; Stereochemistry; Biochemistry; Receptor; Catalysis; Organic chemistry; Crystal structure; Ionic liquid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004629309,0.0001276342,0.0002341975,0.00004273677,0.00004178278,0.000008311263,0.0001922454,0.0002446894,0.00003415978],"category_scores_gemma":[0.0002450801,0.0001064657,0.0002523898,0.00009443323,0.000126538,0.000004135114,0.00003091092,0.0001200519,8.067173e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001371152,"about_ca_system_score_gemma":0.00007011605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001721464,"about_ca_topic_score_gemma":7.014447e-7,"domain_scores_codex":[0.9990788,0.00001139172,0.0004374281,0.0001283144,0.000129605,0.0002145296],"domain_scores_gemma":[0.9990836,0.00005291164,0.0003828763,0.0001519352,0.0002358374,0.00009287215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001757488,0.00006793615,0.001587968,0.0001420639,0.000327828,0.000007266759,0.00002463886,0.000005954315,0.9850426,0.000002360131,0.01167992,0.000935655],"study_design_scores_gemma":[0.0004884636,0.0001414549,0.0006974919,0.000104409,0.0001196243,0.00008567778,0.0005703034,2.393741e-7,0.9898788,0.0000329281,0.00776397,0.0001166292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969562,0.0008235493,0.0004056769,0.0004123358,0.0001458951,0.00006126641,0.00001995961,0.000002873144,0.001172235],"genre_scores_gemma":[0.9944135,0.0002097829,0.002278964,0.00001839294,0.0002195292,9.671679e-7,0.000004796327,0.00001322845,0.002840859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00483615,"threshold_uncertainty_score":0.4341547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754473497530198,"score_gpt":0.2809800650559544,"score_spread":0.2634353300806524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}