{"id":"W2000543353","doi":"10.1038/sj.onc.1209277","title":"Msh2 deficiency leads to chromosomal abnormalities, centrosome amplification, and telomere capping defect","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Biological and Environmental Research; Medical Research Council; Alberta Heritage Foundation for Medical Research; U.S. Department of Energy","keywords":"Biology; MSH2; Telomere; Centrosome; Carcinogenesis; Chromosome instability; Aneuploidy; Molecular biology; Genome instability; Microsatellite instability; Genetics; Minichromosome; DNA mismatch repair; Chromosome segregation; Chromosome; Telomerase; Cell biology; Cancer research; Gene; DNA damage; DNA repair; DNA; Cell cycle; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001598558,0.0001905238,0.0002640462,0.0001143426,0.0001227517,0.00003078254,0.0001091885,0.00009576851,0.0003972722],"category_scores_gemma":[0.0001169624,0.0001799853,0.00007197823,0.0002871869,0.00008194921,0.00006407287,0.00007112508,0.0001307216,0.0001817934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003147505,"about_ca_system_score_gemma":0.0001890603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005216904,"about_ca_topic_score_gemma":0.00008664559,"domain_scores_codex":[0.9985499,0.00002877086,0.0002914783,0.0003959749,0.000312842,0.0004209756],"domain_scores_gemma":[0.9991426,0.00004795145,0.00006135731,0.0003465975,0.0001127964,0.0002886989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001768846,0.0002007218,0.09155171,0.0001945585,0.00005549845,0.00002044366,0.002331998,0.0002355329,0.8542895,0.0006510509,0.003814565,0.0464775],"study_design_scores_gemma":[0.003682662,0.001855379,0.1878698,0.0002980198,0.0003479218,0.001058572,0.0007881362,0.0002542079,0.5049832,0.0001282298,0.2975644,0.001169452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868401,0.003442534,0.0002770028,0.00135358,0.0002017929,0.0004573084,0.00002321733,0.00008238767,0.007322077],"genre_scores_gemma":[0.9917061,0.0001331449,0.005308447,0.001201749,0.0004768814,0.00005640733,0.00001980502,0.00003258979,0.001064863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3493063,"threshold_uncertainty_score":0.7339589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0159254669756203,"score_gpt":0.274795814307509,"score_spread":0.2588703473318887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}