{"id":"W2000543353","doi":"10.1038/sj.onc.1209277","title":"Msh2 deficiency leads to chromosomal abnormalities, centrosome amplification, and telomere capping defect","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Biological and Environmental Research; Medical Research Council; Alberta Heritage Foundation for Medical Research; U.S. Department of Energy","keywords":"Biology; MSH2; Telomere; Centrosome; Carcinogenesis; Chromosome instability; Aneuploidy; Molecular biology; Genome instability; Microsatellite instability; Genetics; Minichromosome; DNA mismatch repair; Chromosome segregation; Chromosome; Telomerase; Cell biology; Cancer research; Gene; DNA damage; DNA repair; DNA; Cell cycle; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060981,0.0008207236,0.0003301449,0.0008263081,0.000417886,0.0003226594,0.0002788744,0.000715318,0.002179939],"category_scores_gemma":[0.0003099219,0.0003424537,0.0002512237,0.0004190744,0.0004177399,0.0001697285,0.0002948545,0.000540467,0.0003864165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003699434,"about_ca_system_score_gemma":0.0002539229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008649452,"about_ca_topic_score_gemma":0.0009955453,"domain_scores_codex":[0.9998803,0.00001818806,0.00001499395,0.00002723707,0.00003380737,0.00002534127],"domain_scores_gemma":[0.9997466,0.0000751456,0.00005275393,0.00002368983,0.00001064362,0.00009107873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001250336,0.0001137125,0.003644972,0.00008968601,0.00006099652,0.02807452,0.00006323597,0.0002952612,0.9624293,0.0004850279,0.0005104785,0.002982433],"study_design_scores_gemma":[0.0003177178,0.0006565282,0.06788821,0.00002351486,0.0001855548,0.1222559,0.0001935754,0.002299315,0.7977952,0.0005647956,0.007776564,0.0000430278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960191,0.0006949839,0.0007672841,0.0001726134,0.00003560741,0.000018959,0.0005034403,0.0001078017,0.001680224],"genre_scores_gemma":[0.9980835,0.0002465396,0.0003707527,0.00002562415,0.0000108614,0.000008405123,0.0002784162,0.00001447,0.0009614794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002179939,"threshold_uncertainty_score":0.007292688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0159254669756203,"score_gpt":0.274795814307509,"score_spread":0.2588703473318887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}