{"id":"W2000551060","doi":"10.1371/journal.pone.0095872","title":"Enhanced Antitumor Efficacy of an Oncolytic Herpes Simplex Virus Expressing an Endostatin–Angiostatin Fusion Gene in Human Glioblastoma Stem Cell Xenografts","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"State Key Laboratory of Molecular Oncology; Chinese Academy of Medical Sciences; National Natural Science Foundation of China; Peking Union Medical College; Faculty of Medicine, University of British Columbia","keywords":"Angiostatin; Oncolytic virus; Stem cell; Cancer research; Endostatin; U87; Herpes simplex virus; Glioma; Biology; In vivo; Genetic enhancement; Medicine; Virus; Angiogenesis; Immunology; Gene; Tumor cells","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474436,0.0002266491,0.0001903841,0.0001986921,0.00006783607,0.0001900535,0.0001021787,0.0001661051,0.0004687821],"category_scores_gemma":[0.00007425057,0.00007528919,0.0001498844,0.0001090027,0.0001573966,0.0001382579,0.0001166248,0.0002784589,0.00008576365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224492,"about_ca_system_score_gemma":0.0002041083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007925331,"about_ca_topic_score_gemma":0.0007611492,"domain_scores_codex":[0.9999281,0.00001431135,0.000006292129,0.00001235247,0.00002031884,0.00001859685],"domain_scores_gemma":[0.9999588,0.00001193706,0.000008822428,0.000005481795,0.000004958684,0.000009986715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007576235,0.00002283769,0.00009707792,0.00001186581,0.000003509291,0.00001543707,0.0000100454,0.0000754077,0.998708,0.00008657854,0.00001414641,0.0008794255],"study_design_scores_gemma":[0.00001134639,0.0003753026,0.001038678,0.000001254008,0.00001072715,0.00005744816,0.00000649389,0.0009053181,0.9969044,0.00001889979,0.0006685288,0.000001650462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973374,0.0005822189,0.001438582,0.00002496731,0.0000130791,0.00001683487,0.0001093409,0.0000268291,0.0004507027],"genre_scores_gemma":[0.9975622,0.0003012954,0.001260895,0.000006881188,0.000003292201,0.00001319947,0.0001378863,0.00000563439,0.000708661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007925331,"threshold_uncertainty_score":0.001613975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02925840240890703,"score_gpt":0.2955240079895243,"score_spread":0.2662656055806172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}