{"id":"W2000551060","doi":"10.1371/journal.pone.0095872","title":"Enhanced Antitumor Efficacy of an Oncolytic Herpes Simplex Virus Expressing an Endostatin–Angiostatin Fusion Gene in Human Glioblastoma Stem Cell Xenografts","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"State Key Laboratory of Molecular Oncology; Chinese Academy of Medical Sciences; National Natural Science Foundation of China; Peking Union Medical College; Faculty of Medicine, University of British Columbia","keywords":"Angiostatin; Oncolytic virus; Stem cell; Cancer research; Endostatin; U87; Herpes simplex virus; Glioma; Biology; In vivo; Genetic enhancement; Medicine; Virus; Angiogenesis; Immunology; Gene; Tumor cells","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004516575,0.0002527502,0.0003749472,0.0001780068,0.0001251711,0.00004294617,0.0004034113,0.000140587,0.00005376962],"category_scores_gemma":[0.00004254739,0.0002670647,0.00007281326,0.0002167037,0.0001190665,0.00001961735,0.0001342662,0.000136236,0.000009139287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003273075,"about_ca_system_score_gemma":0.00009055241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008059901,"about_ca_topic_score_gemma":0.0007589595,"domain_scores_codex":[0.9975777,0.0004708467,0.0004540631,0.0005753603,0.0004326025,0.0004894765],"domain_scores_gemma":[0.9986811,0.00005257042,0.000205232,0.0007265059,0.0001409038,0.0001936992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001978345,0.003043433,0.00007498492,0.00009831401,0.00004144607,0.000007333287,0.0004564836,0.0001741319,0.9696684,0.000001860608,0.000006592953,0.0244487],"study_design_scores_gemma":[0.002670489,0.008689544,0.0005877709,0.0001019483,0.00002436277,9.116965e-7,0.000123708,0.0008696523,0.9865875,0.00001439516,0.00004787171,0.0002818528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988443,0.0001932819,0.0002126992,0.00001185201,0.00001738317,0.0005157461,0.00004035877,0.00003018174,0.0001341991],"genre_scores_gemma":[0.9975942,0.00005128344,0.001750597,0.00006868882,0.0001888503,0.00004203671,0.0001389797,0.00007163308,0.00009370197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02416684,"threshold_uncertainty_score":0.9999782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02925840240890703,"score_gpt":0.2955240079895243,"score_spread":0.2662656055806172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}