{"id":"W2000557745","doi":"10.1016/j.jneuroim.2014.08.547","title":"Abnormal responses of CD8 + CD161high mucosal associated invariant T (MAIT) cells and CCR2 + CCR5 + CD4 T cells contribute to disrupted balance of effector and regulatory T cells in pediatric-onset MS","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Manitoba; University of British Columbia; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"FOXP3; CD8; Immunology; Flow cytometry; Multiple sclerosis; Peripheral blood mononuclear cell; Effector; Biology; Medicine; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001625245,0.0004545987,0.001674086,0.0008567062,0.0001210785,0.00001965812,0.0005682721,0.0007593578,0.00007090881],"category_scores_gemma":[0.0007887803,0.0004026812,0.000195956,0.000429925,0.0007461242,0.0001715261,0.0003755689,0.001111607,0.00003454422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006573191,"about_ca_system_score_gemma":0.0001926357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215902,"about_ca_topic_score_gemma":0.00003420486,"domain_scores_codex":[0.9945365,0.002397265,0.001693078,0.0004752965,0.0001279765,0.0007698631],"domain_scores_gemma":[0.9947048,0.002753236,0.001625887,0.0004805627,0.0003465151,0.00008904113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003825001,0.0005737653,0.02298038,0.00009031767,0.0002666422,0.0001065167,0.0004049085,0.00003019733,0.9701257,0.00008128132,0.001213062,0.0003022609],"study_design_scores_gemma":[0.007914807,0.00426912,0.3725268,0.0001091909,0.0002191455,0.0006082793,0.00006564786,0.00001582036,0.6105762,0.00008414232,0.003250207,0.0003607472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932127,0.003591022,0.00004474914,0.0003723925,0.002156179,0.0003739902,0.0001875665,0.00002333497,0.00003804687],"genre_scores_gemma":[0.9975297,0.001668904,0.0001148173,0.0002054453,0.0000577843,0.000006099844,0.0000178378,0.00004111671,0.0003583322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3595495,"threshold_uncertainty_score":0.9998425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006716629338929434,"score_gpt":0.2129948313389622,"score_spread":0.2062782020000328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}