{"id":"W2000579331","doi":"10.1006/bbrc.2000.2402","title":"Interferon-Dependent Activation of the Serine Kinase PI 3′-Kinase Requires Engagement of the IRS Pathway but Not the Stat Pathway","year":2000,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health; Medical Research Council Canada","keywords":"MAP kinase kinase kinase; Cyclin-dependent kinase 9; JAK-STAT signaling pathway; Cell biology; Tyrosine phosphorylation; Receptor tyrosine kinase; Mitogen-activated protein kinase kinase; Biology; Molecular biology; Tyrosine kinase; Protein kinase B; MAP2K7; Signal transduction; Cancer research; Phosphorylation; Chemistry; Cyclin-dependent kinase 2; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006226191,0.0001331589,0.0002011374,0.00004678058,0.0005088147,0.00002923747,0.0008840108,0.00006806717,0.0001392882],"category_scores_gemma":[0.0006821707,0.00006361646,0.0001810794,0.0004723262,0.00130192,0.0000621043,0.0007727587,0.00089882,0.000007818093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008724898,"about_ca_system_score_gemma":0.0001909423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004567461,"about_ca_topic_score_gemma":0.00002065,"domain_scores_codex":[0.9980117,0.0004934875,0.0003854149,0.0002165967,0.0006538407,0.0002389492],"domain_scores_gemma":[0.9967643,0.0008977838,0.0001077676,0.001768189,0.0003631107,0.00009885681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002456326,0.0007290498,0.00007775362,0.0000529413,0.00004178473,3.086652e-7,0.0003113067,0.000001802546,0.9853,0.002603272,0.0005083783,0.01012775],"study_design_scores_gemma":[0.0003789924,0.0002755069,0.00534093,0.0002908632,0.00002647475,0.000003299318,0.0003849048,0.0003451034,0.9837146,0.0004118925,0.008758457,0.00006897483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812347,0.0001399421,0.000009142081,0.01614479,0.00003004341,0.0005939361,0.000122174,0.00001366501,0.001711665],"genre_scores_gemma":[0.9984528,0.0003434951,0.00008953749,0.0001703457,0.00007572589,0.00008767033,0.00002602934,0.00001290962,0.0007414856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01721816,"threshold_uncertainty_score":0.4796979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027536117974713,"score_gpt":0.3617792381676461,"score_spread":0.2590256263701747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}