{"id":"W2000590100","doi":"10.1007/s11095-006-9111-5","title":"Transition Metal-Mediated Liposomal Encapsulation of Irinotecan (CPT-11) Stabilizes the Drug in the Therapeutically Active Lactone Conformation","year":2006,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Liposome; Chemistry; Irinotecan; SN-38; Stereochemistry; Phospholipid; Drug; Lactone; Chromatography; Drug delivery; Membrane; Biophysics; Combinatorial chemistry; Organic chemistry; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134084,0.0001468905,0.0001094067,0.00008269122,0.0001366678,0.0002317246,0.0001167196,0.000198136,0.0008956757],"category_scores_gemma":[0.0001308009,0.00009220309,0.0001014212,0.0000549428,0.0002311386,0.0002309242,0.000138462,0.0002815977,0.0003915305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004828983,"about_ca_system_score_gemma":0.0002411024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000678548,"about_ca_topic_score_gemma":0.001080171,"domain_scores_codex":[0.999951,0.000007543775,0.000002844539,0.00001410523,0.00001291059,0.00001162636],"domain_scores_gemma":[0.9999558,0.000008746852,0.00001897567,0.000004259758,0.000005226836,0.000007059813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000774807,0.00001272033,0.00005509552,0.00002221793,0.000002734511,0.00002927203,0.00001337888,0.0001331879,0.9977378,0.0002393064,0.00005365411,0.001623204],"study_design_scores_gemma":[0.000009694287,0.00007631571,0.0002300607,0.000001693106,0.000004703385,0.00005155036,0.000003801091,0.0005568809,0.9979234,0.00001372487,0.001125383,0.000002796133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926699,0.0008069598,0.003956815,0.0001466053,0.00003031629,0.00002399092,0.00005254591,0.0001026004,0.002210281],"genre_scores_gemma":[0.9948897,0.0002825432,0.0020777,0.00003630514,0.000005342064,0.000008401127,0.00003923733,0.00001230788,0.002648468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008956757,"threshold_uncertainty_score":0.00350374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07871530120952937,"score_gpt":0.3862765323058422,"score_spread":0.3075612310963128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}