{"id":"W2000596494","doi":"10.1016/j.jmb.2004.12.049","title":"The Axial Channel of the 20S Proteasome Opens Upon Binding of the PA200 Activator","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; Health Sciences Centre","funders":"Canadian Institutes of Health Research","keywords":"Biophysics; Allosteric regulation; Activator (genetics); Chemistry; Proteasome; Cryo-electron microscopy; Folding (DSP implementation); ATP hydrolysis; Cleavage (geology); Crystallography; Protein folding; Stereochemistry; Biochemistry; Enzyme; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007531656,0.0001571151,0.0002464522,0.0000380277,0.0001550121,0.00001155082,0.0009112008,0.0001623155,0.00001324229],"category_scores_gemma":[0.0004161882,0.00007481138,0.0003799153,0.0001395458,0.000262128,0.000005266218,0.000311051,0.0002955488,0.000001641888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000210154,"about_ca_system_score_gemma":0.0002335176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006792135,"about_ca_topic_score_gemma":0.00001202276,"domain_scores_codex":[0.9984339,0.0004461744,0.0005065343,0.0001541511,0.0001945002,0.0002646878],"domain_scores_gemma":[0.9983987,0.00003894452,0.0008364235,0.0004626499,0.0002061428,0.00005712515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001584515,0.00005418543,0.0003921674,0.00001055557,0.0001249581,0.000001817278,0.00005733758,0.0000631823,0.9965388,0.0004570781,0.0002274621,0.001914071],"study_design_scores_gemma":[0.0005529366,0.0003968679,0.0005995533,0.00004608908,0.00003221678,0.0001648335,0.00006985536,0.00001293132,0.9785144,0.0004094079,0.01911004,0.00009088377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951687,0.001130576,0.0003461592,0.002198629,0.0004133091,0.0003684956,0.00002608118,0.000001594271,0.0003464763],"genre_scores_gemma":[0.9988172,0.0001684176,0.0002757749,0.000240243,0.0003414646,0.000009750789,0.000002511162,0.00001774951,0.0001268821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01888258,"threshold_uncertainty_score":0.3050719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162318052891825,"score_gpt":0.259709213883739,"score_spread":0.2480860333548207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}