{"id":"W2000601138","doi":"10.1074/jbc.m109893200","title":"Bcl-2 and Bcl-xL Inhibit CD95-mediated Apoptosis by Preventing Mitochondrial Release of Smac/DIABLO and Subsequent Inactivation of X-linked Inhibitor-of-Apoptosis Protein","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität Innsbruck; European Commission; Université Laval","keywords":"XIAP; Apoptosis; Apoptosome; Fas receptor; Inhibitor of apoptosis; Cell biology; Cytochrome c; Caspase; Inhibitor of apoptosis domain; Caspase 8; Intrinsic apoptosis; Mitochondrion; Biology; Caspase-9; Phosphatidylserine; Molecular biology; Programmed cell death; Biochemistry; Phospholipid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002263598,0.0001640698,0.0003664534,0.00003430263,0.00003559021,0.000008698899,0.00009477074,0.0003958184,0.0000380347],"category_scores_gemma":[0.0003477456,0.0001250458,0.0001297645,0.00009553021,0.0001566438,0.00001002591,0.0000784458,0.0001600579,1.045668e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000178331,"about_ca_system_score_gemma":0.00002249352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007064728,"about_ca_topic_score_gemma":2.149176e-7,"domain_scores_codex":[0.9986619,0.00006373701,0.0007284943,0.0002176201,0.00017853,0.0001497547],"domain_scores_gemma":[0.9985678,0.00003712101,0.0009521677,0.0001254241,0.000213713,0.0001038398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002362902,0.000213901,0.0006217943,0.0001609282,0.00005702925,5.416198e-7,0.00002560003,0.000007182425,0.9962177,0.000004147494,0.0001343577,0.002320511],"study_design_scores_gemma":[0.00115659,0.0005364938,0.0003067072,0.0001658005,0.00003886257,0.0000111366,0.00006630135,0.00009868819,0.9971575,0.00006683167,0.0002659393,0.0001291231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978694,0.00156677,0.0001816434,0.00007123456,0.00004814056,0.0001725079,0.00002692898,0.000003065701,0.00006025519],"genre_scores_gemma":[0.9974529,0.001195936,0.0009949239,0.000009005595,0.0001725717,0.000005441529,0.00005232028,0.000009883526,0.0001070426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002191388,"threshold_uncertainty_score":0.5099221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344882939040051,"score_gpt":0.214466426557626,"score_spread":0.2010175971672255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}