{"id":"W2000601138","doi":"10.1074/jbc.m109893200","title":"Bcl-2 and Bcl-xL Inhibit CD95-mediated Apoptosis by Preventing Mitochondrial Release of Smac/DIABLO and Subsequent Inactivation of X-linked Inhibitor-of-Apoptosis Protein","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität Innsbruck; European Commission; Université Laval","keywords":"XIAP; Apoptosis; Apoptosome; Fas receptor; Inhibitor of apoptosis; Cell biology; Cytochrome c; Caspase; Inhibitor of apoptosis domain; Caspase 8; Intrinsic apoptosis; Mitochondrion; Biology; Caspase-9; Phosphatidylserine; Molecular biology; Programmed cell death; Biochemistry; Phospholipid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002292515,0.0004897591,0.0002349317,0.0002441751,0.0001184603,0.0003510537,0.0003157896,0.0003515044,0.001515083],"category_scores_gemma":[0.0002044334,0.000133153,0.000266609,0.000171005,0.0001793128,0.0002775254,0.0002201088,0.0006380298,0.0003873775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245718,"about_ca_system_score_gemma":0.0003326001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002353056,"about_ca_topic_score_gemma":0.0004575802,"domain_scores_codex":[0.9998179,0.00004020665,0.00002573707,0.00001702947,0.00005457351,0.00004455371],"domain_scores_gemma":[0.9998978,0.0000171505,0.00002812299,0.00001385718,0.00001073757,0.00003231563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000573561,0.0004170824,0.0004269931,0.0001790753,0.00003476291,0.0001518847,0.00003151681,0.0001541199,0.9865329,0.0007724101,0.0002527589,0.0104728],"study_design_scores_gemma":[0.0002677443,0.001708533,0.00288747,0.00001043924,0.00003539626,0.0007821665,0.00002044786,0.001225111,0.9856426,0.0001544169,0.00725893,0.000006771627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830117,0.007550699,0.005547571,0.0002820376,0.00009557998,0.00008163282,0.0002202002,0.0001714486,0.003038996],"genre_scores_gemma":[0.98901,0.002664028,0.004357958,0.0001158336,0.00003758421,0.0001066814,0.0004919695,0.000010708,0.003205168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515083,"threshold_uncertainty_score":0.005068481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344882939040051,"score_gpt":0.214466426557626,"score_spread":0.2010175971672255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}