{"id":"W2000644717","doi":"10.1021/nn404305e","title":"Thermodynamic Basis for Engineering High-Affinity, High-Specificity Binding-Induced DNA Clamp Nanoswitches","year":2013,"lang":"en","type":"article","venue":"ACS Nano","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases","keywords":"DNA; Clamp; Biophysics; Materials science; Basis (linear algebra); Chemistry; Nanotechnology; Biochemistry; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002868172,0.0002570307,0.00028982,0.0001824414,0.0003591505,0.0006715219,0.0006867216,0.0004395556,0.001718802],"category_scores_gemma":[0.0005779293,0.0003800345,0.0002306052,0.0001291742,0.0005512026,0.0007408353,0.0004335542,0.0009042533,0.0004060942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008285472,"about_ca_system_score_gemma":0.000478078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004713311,"about_ca_topic_score_gemma":0.001066218,"domain_scores_codex":[0.9998817,0.00001086628,0.00001088215,0.00002960101,0.00004288601,0.00002399395],"domain_scores_gemma":[0.9999208,0.00002988976,0.00001281936,0.000008547665,0.00001268907,0.00001523812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006872471,0.0002433941,0.0009734171,0.0002776106,0.00002552674,0.0003722032,0.0001163937,0.07204136,0.7324092,0.1812286,0.0007529524,0.01149068],"study_design_scores_gemma":[0.00006955693,0.0003959904,0.001027256,0.00002562857,0.00002017309,0.0002821554,0.0000971332,0.4746331,0.4548129,0.05903355,0.009516428,0.00008620087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7403987,0.001757451,0.2264404,0.00108701,0.0004352666,0.0003054813,0.0002285038,0.0007419865,0.02860515],"genre_scores_gemma":[0.9806805,0.000697695,0.01592414,0.0001354519,0.00002964157,0.0001570519,0.000110166,0.00008945356,0.002175809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718802,"threshold_uncertainty_score":0.006011546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055317686567319,"score_gpt":0.2311366367011413,"score_spread":0.2205834598354681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}