{"id":"W2000651827","doi":"10.1016/j.actbio.2011.01.027","title":"Lipid substitution on low molecular weight (0.6–2.0 kDa) polyethylenimine leads to a higher zeta potential of plasmid DNA and enhances transgene expression","year":2011,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Ministry of Advanced Education, Government of Alberta","keywords":"Polyethylenimine; Plasmid; Transgene; Zeta potential; Materials science; DNA; Biophysics; Substitution (logic); Cell biology; Molecular biology; Transfection; Nanotechnology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007355113,0.0002122228,0.0002020044,0.00007824949,0.00004747833,0.00002142034,0.0002042686,0.0002013951,0.0001801214],"category_scores_gemma":[0.000007950993,0.0001813828,0.00007357319,0.00006191181,0.00009618897,0.00001158173,0.00007586831,0.00002801401,0.00001785751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006150735,"about_ca_system_score_gemma":0.00002239287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003439396,"about_ca_topic_score_gemma":0.000004359861,"domain_scores_codex":[0.9989185,0.00005442539,0.0002579015,0.0004013982,0.0001400274,0.0002277571],"domain_scores_gemma":[0.9994417,0.000002099959,0.00009098983,0.0003081592,0.00005655755,0.0001004481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00110648,0.0001078199,0.00005671046,0.000036844,0.00003885083,0.00000832299,0.0001061831,7.311337e-7,0.997525,0.00002960166,0.0007741011,0.0002094066],"study_design_scores_gemma":[0.000462365,0.0009468324,0.002080732,0.0000768091,0.00002893681,0.000007064366,0.00001091031,0.000001846144,0.9945216,0.0000172558,0.001624503,0.0002211115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977418,0.0001224521,0.000340583,0.0000875913,0.001277325,0.0001573951,0.00007011024,0.00001450358,0.0001882901],"genre_scores_gemma":[0.9987923,0.0001217078,0.0003541085,0.0001524125,0.0002551864,0.00001871526,0.0001034099,0.0000201663,0.0001819878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003003314,"threshold_uncertainty_score":0.7396578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203847919320351,"score_gpt":0.2264504817699569,"score_spread":0.2144120025767534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}