{"id":"W2000651827","doi":"10.1016/j.actbio.2011.01.027","title":"Lipid substitution on low molecular weight (0.6–2.0 kDa) polyethylenimine leads to a higher zeta potential of plasmid DNA and enhances transgene expression","year":2011,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Ministry of Advanced Education, Government of Alberta","keywords":"Polyethylenimine; Plasmid; Transgene; Zeta potential; Materials science; DNA; Biophysics; Substitution (logic); Cell biology; Molecular biology; Transfection; Nanotechnology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839159,0.0004067981,0.0002527107,0.0001411897,0.0001070649,0.0002774598,0.0002023923,0.0003164743,0.001106726],"category_scores_gemma":[0.0002297778,0.0001533419,0.0002726078,0.0001506178,0.0002796438,0.0002416644,0.0002060194,0.0004400581,0.0004820679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002132372,"about_ca_system_score_gemma":0.0001546902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003674829,"about_ca_topic_score_gemma":0.0004578622,"domain_scores_codex":[0.9998868,0.00002188161,0.00001411819,0.00002312556,0.0000316409,0.00002255462],"domain_scores_gemma":[0.9998135,0.0000456579,0.00006554985,0.00002182426,0.00002369286,0.00002973752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002108465,0.000002972912,0.00001501695,0.000006964295,9.343609e-7,0.000008918511,0.000002388216,0.000008129718,0.9997814,0.00001448504,0.000002427779,0.0001352291],"study_design_scores_gemma":[0.000003563112,0.00004173827,0.0003692225,0.000001245591,0.000004821696,0.0000463204,0.000003015136,0.00009736522,0.9991583,0.000009992395,0.0002628597,0.000001631707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931252,0.0003461824,0.005259151,0.00008027552,0.00002311154,0.000020267,0.00007091374,0.00006620953,0.001008652],"genre_scores_gemma":[0.993077,0.000361376,0.003755246,0.00006142262,0.000007068044,0.00001861454,0.0002064455,0.00005635273,0.002456314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106726,"threshold_uncertainty_score":0.003702402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203847919320351,"score_gpt":0.2264504817699569,"score_spread":0.2144120025767534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}