{"id":"W2000692947","doi":"10.1038/onc.2012.189","title":"The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Cancer Research Society; Kræftens Bekæmpelse; Cancer Research UK; Conquer Cancer Foundation","keywords":"Ubiquitin ligase; RAC1; Biology; Cell biology; Cell migration; Ubiquitin; CDC42; Motility; Cell; Biochemistry; GTPase; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003996617,0.0001186539,0.00008527562,0.00001453184,0.0002625812,0.00004731109,0.00009977598,0.00009937175,0.00001859032],"category_scores_gemma":[0.00008214833,0.00009205316,0.00006718088,0.00005491541,0.00003520746,0.0000106018,0.0000365206,0.00005387188,0.00001562158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001793254,"about_ca_system_score_gemma":0.00002886642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001588002,"about_ca_topic_score_gemma":0.00001852235,"domain_scores_codex":[0.9991148,0.0001084603,0.0002012517,0.0001639783,0.0001476563,0.0002638805],"domain_scores_gemma":[0.9994622,0.00002529365,0.000140546,0.0002189255,0.00006692413,0.00008611249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004197442,0.00003197071,0.0005124387,0.000004652026,0.00001129876,1.271962e-7,0.00002209525,0.00004914313,0.9905059,0.00007853576,0.004912019,0.003829793],"study_design_scores_gemma":[0.0004251472,0.00003832775,0.0002636875,0.00000516654,0.00001450144,0.000004132287,0.00003843087,0.0004737015,0.8657439,0.00002205617,0.1328595,0.0001114147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793299,0.008546997,0.009953258,0.0005932673,0.0001644754,0.0003109938,0.00002252443,0.00001997628,0.001058633],"genre_scores_gemma":[0.9955375,0.00009639363,0.0009104127,0.0001471988,0.0004291727,0.00004518968,0.0003531524,0.00001917819,0.00246177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1279475,"threshold_uncertainty_score":0.3753819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009199016444406386,"score_gpt":0.2381551705575216,"score_spread":0.2289561541131152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}