{"id":"W2000692947","doi":"10.1038/onc.2012.189","title":"The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Cancer Research Society; Kræftens Bekæmpelse; Cancer Research UK; Conquer Cancer Foundation","keywords":"Ubiquitin ligase; RAC1; Biology; Cell biology; Cell migration; Ubiquitin; CDC42; Motility; Cell; Biochemistry; GTPase; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632659,0.0005018584,0.0002174669,0.000517434,0.0004836082,0.0007794002,0.0003866836,0.0004032931,0.00122439],"category_scores_gemma":[0.0002650144,0.0003245754,0.0001920132,0.000226991,0.0004346019,0.0004716552,0.00040676,0.0008878866,0.0007474344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008964249,"about_ca_system_score_gemma":0.000283435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008154899,"about_ca_topic_score_gemma":0.001529614,"domain_scores_codex":[0.9998148,0.00002010768,0.00001126584,0.00004071855,0.00004737504,0.00006569651],"domain_scores_gemma":[0.9997396,0.00002844997,0.00008634927,0.00003555114,0.00003932695,0.00007067247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001631214,0.00001186317,0.0003066256,0.00001888762,0.000004436374,0.00007690611,0.0000139763,0.0001177982,0.9969586,0.000722394,0.0001430868,0.001462199],"study_design_scores_gemma":[0.00001438852,0.00003422264,0.004084254,0.000003737011,0.000007021652,0.0002729658,0.00003707383,0.002659273,0.988844,0.0002701858,0.003767084,0.00000575181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888656,0.003182148,0.003916036,0.0004784178,0.00007475403,0.00001141427,0.0003892302,0.0002372742,0.002845147],"genre_scores_gemma":[0.9957473,0.0006223948,0.000831484,0.00004345573,0.00001003642,0.000009270683,0.000240879,0.00005430361,0.002440854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122439,"threshold_uncertainty_score":0.006504059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009199016444406386,"score_gpt":0.2381551705575216,"score_spread":0.2289561541131152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}