{"id":"W2000704978","doi":"10.1074/jbc.m110.152744","title":"Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Caspase; NLRP1; Gene isoform; Biology; Cell biology; Alternative splicing; Molecular biology; Programmed cell death; Gene; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003762894,0.0005857937,0.0006536474,0.0003862138,0.00016389,0.0003574222,0.0002987692,0.0004433894,0.003724084],"category_scores_gemma":[0.0004456772,0.0001581531,0.0006041428,0.0002106124,0.0002074388,0.0003190107,0.0002472923,0.001247367,0.001551611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000175129,"about_ca_system_score_gemma":0.0002836764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001825613,"about_ca_topic_score_gemma":0.0001589563,"domain_scores_codex":[0.999485,0.00009399307,0.00007602968,0.00008952807,0.0001747842,0.00008068264],"domain_scores_gemma":[0.999729,0.00005166408,0.00005097231,0.00004638909,0.00006983506,0.00005215133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002812696,0.0001430232,0.0002228995,0.0001979245,0.00002005021,0.00006907371,0.00001570475,0.00006630911,0.9892619,0.0001983357,0.0002833721,0.009240238],"study_design_scores_gemma":[0.00008877181,0.001063801,0.0022315,0.00002721423,0.00002918458,0.0009526614,0.00001683407,0.0009626445,0.983282,0.0001667613,0.01117111,0.000007634774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9269938,0.03327087,0.02457298,0.0007922383,0.0009176511,0.0002433382,0.001089987,0.0005239105,0.01159521],"genre_scores_gemma":[0.9674969,0.01068267,0.01136235,0.0002876981,0.0001546421,0.0001906751,0.001781251,0.00007858419,0.007965271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003724084,"threshold_uncertainty_score":0.01245832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538951401791678,"score_gpt":0.2496312365031068,"score_spread":0.23424172248519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}