{"id":"W2000717209","doi":"10.1182/blood-2014-04-569640","title":"TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia","funders":"Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; University of British Columbia; Michael Smith Health Research BC; Canadian Blood Services","keywords":"Proteases; Proteome; Biochemistry; Biology; Proteolysis; Storage protein; Platelet; Protease; Cell biology; Chemistry; Enzyme; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002371926,0.0001915942,0.0005712202,0.0001502812,0.00005484587,0.00001546309,0.00009813059,0.0001060957,0.00003039368],"category_scores_gemma":[0.00007849211,0.0001648063,0.00007980243,0.0001239036,0.00005019986,0.00009564813,0.00003858974,0.0001579976,0.00001586141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004190963,"about_ca_system_score_gemma":0.00006961212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007722501,"about_ca_topic_score_gemma":0.00004350507,"domain_scores_codex":[0.9987533,0.00004635696,0.0003858783,0.0002984233,0.0002360147,0.0002800234],"domain_scores_gemma":[0.999358,0.00001703705,0.0001972582,0.0002714949,0.0000628247,0.00009337855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004430019,0.01470216,0.1273863,0.003430545,0.0005869123,0.007923102,0.002925488,0.00003489213,0.8141695,0.0004018944,0.00003138216,0.02796489],"study_design_scores_gemma":[0.07296689,0.007227507,0.2514672,0.004149454,0.002398347,0.002767362,0.0008630991,0.001045265,0.6498126,0.005486094,0.0002338032,0.001582372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967671,0.0003864928,0.00002965779,0.00005959392,0.00001711369,0.001084347,0.000006069235,0.00003327861,0.00161636],"genre_scores_gemma":[0.9987486,0.00001158181,0.0005718414,0.00005805194,0.00003463562,0.00009639745,0.00002124523,0.00003247998,0.0004251417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1643569,"threshold_uncertainty_score":0.6720605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489836080817084,"score_gpt":0.2601747215558813,"score_spread":0.2452763607477104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}