{"id":"W2000726801","doi":"10.1021/ja036596i","title":"Cross-Linked Bis-hemoglobins:  Connections and Oxygen Binding","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Cooperativity; Hemoglobin; Steric effects; Oxygen; Crystallography; Cooperative binding; Stereochemistry; Covalent bond; Biophysics; Binding site; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508834,0.0002814871,0.00008120278,0.00009691623,0.00008461498,0.0001277005,0.0002943731,0.0002498204,0.000963983],"category_scores_gemma":[0.0002986074,0.0001480165,0.00007585902,0.0001207074,0.0001333447,0.0002397902,0.0001599469,0.0004428198,0.0001689146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193038,"about_ca_system_score_gemma":0.00007553448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003052313,"about_ca_topic_score_gemma":0.0003042954,"domain_scores_codex":[0.9998901,0.00002795954,0.000007827621,0.00003237813,0.00002494769,0.00001681287],"domain_scores_gemma":[0.9997842,0.00004127147,0.00007630089,0.00001893752,0.0000244044,0.0000548965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006713808,0.0000234028,0.000185298,0.00001340377,0.000005802324,0.00001265625,0.000008942512,0.0001199362,0.9985667,0.0001611802,0.00003052941,0.0008050806],"study_design_scores_gemma":[0.00001249324,0.0001273466,0.001810572,0.000004019267,0.00001499038,0.00009354942,0.000006832167,0.001138321,0.9955286,0.00009419768,0.00116637,0.000002735199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956107,0.0005118665,0.003266376,0.00004136571,0.00001190764,0.000009891186,0.00005044262,0.00003009365,0.0004675293],"genre_scores_gemma":[0.9951749,0.0003715258,0.003118779,0.00006988153,0.000005993795,0.0000127711,0.0002303849,0.00001634415,0.0009994218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000963983,"threshold_uncertainty_score":0.00322485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008529805891108659,"score_gpt":0.2599413804026586,"score_spread":0.2514115745115499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}