{"id":"W2000746048","doi":"10.1002/cncr.25321","title":"Cationic polymer‐mediated small interfering RNA delivery for P‐glycoprotein down‐regulation in tumor cells","year":2010,"lang":"en","type":"article","venue":"Cancer","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Alberta Cancer Foundation","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Small interfering RNA; Glycoprotein; Cationic polymerization; RNA; Cancer research; Cell biology; Molecular biology; Biochemistry; Biology; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008121541,0.0001176327,0.0001028462,0.00005730505,0.00003733749,0.00002158205,0.0001524568,0.0001110945,0.000106766],"category_scores_gemma":[0.00002534887,0.0001195658,0.0000586782,0.00006624116,0.00003658224,0.000006458055,0.00004343033,0.0001015403,0.00001636198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002605751,"about_ca_system_score_gemma":0.0001156953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002924087,"about_ca_topic_score_gemma":0.002612138,"domain_scores_codex":[0.9992779,0.0000131089,0.0001837163,0.000272163,0.00004704865,0.0002060547],"domain_scores_gemma":[0.9995695,0.0000105781,0.00007012489,0.0002103713,0.00009086614,0.00004857082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001088997,0.0000184939,0.0006857212,0.00001696999,0.00001396822,7.048159e-7,0.00004192589,0.00008152999,0.9925909,0.00001374451,0.0004605462,0.005966562],"study_design_scores_gemma":[0.0004722962,0.0000953279,0.002447285,0.00002825571,0.000007643953,0.000001640602,0.0000253316,0.0006241259,0.9914531,0.00002926035,0.004657734,0.0001579696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974665,0.0006181068,0.000709614,0.0000934837,0.0005566985,0.0002808199,0.0000487797,0.00001024221,0.0002157432],"genre_scores_gemma":[0.9979708,0.00009162463,0.0002002862,0.0002823241,0.0003384296,0.0002349058,0.0001282164,0.0000189765,0.0007344316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005808592,"threshold_uncertainty_score":0.487575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009899844811942275,"score_gpt":0.2389968304050596,"score_spread":0.2290969855931173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}