{"id":"W2000765908","doi":"10.1128/aac.00547-09","title":"TEM-168, a Heretofore Laboratory-Derived TEM β-Lactamase Variant Found in an <i>Escherichia coli</i> Clinical Isolate","year":2009,"lang":"en","type":"letter","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada","funders":"","keywords":"Etest; Broth microdilution; Sulbactam; Cefepime; Escherichia coli; Microbiology; Ampicillin; Ceftazidime; Cefotaxime; Biology; Antimicrobial; Imipenem; Antibiotics; Bacteria; Genetics; Antibiotic resistance; Gene; Minimum inhibitory concentration; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002076717,0.0004021962,0.0003770223,0.0002907144,0.0002014251,0.0004048515,0.0003594821,0.0003227733,0.001415441],"category_scores_gemma":[0.0003711456,0.0001374201,0.0002661328,0.0002902372,0.0003101841,0.0001751245,0.0002722218,0.0005991563,0.0007910241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001917508,"about_ca_system_score_gemma":0.0002910263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006582763,"about_ca_topic_score_gemma":0.001018288,"domain_scores_codex":[0.9996299,0.00007912096,0.00006326701,0.00009971445,0.00008739954,0.00004066751],"domain_scores_gemma":[0.9997744,0.0000367471,0.00007556068,0.0000350113,0.00003269502,0.00004559924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004514996,0.0001989091,0.009039553,0.0001712302,0.00001909372,0.001629127,0.00009696479,0.0000640068,0.9803672,0.0001718023,0.0007657412,0.007024894],"study_design_scores_gemma":[0.00007429333,0.002520567,0.03581094,0.00005592242,0.00007875006,0.02386392,0.0002939291,0.0003457902,0.913246,0.0000870627,0.02358991,0.00003303522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988938,0.001208869,0.003195672,0.0002800869,0.000121429,0.0002107994,0.00292957,0.0001194971,0.002996018],"genre_scores_gemma":[0.9735174,0.0009322687,0.01458948,0.0002166165,0.00005694625,0.00009107192,0.007608865,0.00008843626,0.002898758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001415441,"threshold_uncertainty_score":0.004735112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516206574317073,"score_gpt":0.2803041191966928,"score_spread":0.2651420534535221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}