{"id":"W2000765979","doi":"10.1007/s10549-008-9974-8","title":"Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology","year":2008,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Coalition for Research in Women's Health; University of Toronto","funders":"","keywords":"Breast cancer; CDKN2A; CHEK2; Genetic predisposition; Oncology; Medicine; Cancer; Internal medicine; Population; Pathology; Biology; Disease; Germline mutation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006849242,0.0006393861,0.0008587664,0.001073139,0.0006063394,0.0008163587,0.0004734999,0.0003563877,0.002280406],"category_scores_gemma":[0.001366786,0.0003041397,0.0009877769,0.0006198921,0.0008170253,0.0002905575,0.001526933,0.0005491655,0.0002339082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004794126,"about_ca_system_score_gemma":0.00110444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01098942,"about_ca_topic_score_gemma":0.01018201,"domain_scores_codex":[0.9995614,0.0001282105,0.00001467012,0.0001106939,0.0000512181,0.0001338431],"domain_scores_gemma":[0.9994022,0.000209999,0.0001103279,0.0001366013,0.00004564038,0.00009524345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00910871,0.0006377418,0.705534,0.0002655407,0.001621625,0.003132837,0.001720844,0.01968809,0.1196845,0.05300445,0.001213905,0.08438772],"study_design_scores_gemma":[0.0005030558,0.00224328,0.8676179,0.00007472815,0.002021946,0.008220901,0.001626859,0.05243739,0.01676027,0.0366159,0.01178322,0.00009455808],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854078,0.0002764907,0.01073706,0.0002227949,0.00000727022,0.00004912088,0.0003409699,0.0000368084,0.002921759],"genre_scores_gemma":[0.9933485,0.000427755,0.003015709,0.00004603609,0.000006178905,0.00004433336,0.000223935,0.00002361746,0.002863892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01098942,"threshold_uncertainty_score":0.02185094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05069930795192486,"score_gpt":0.329127639426374,"score_spread":0.2784283314744492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}