{"id":"W2000813464","doi":"10.1371/journal.pbio.1000188","title":"Dual Regulation by Pairs of Cyclin-Dependent Protein Kinases and Histone Deacetylases Controls G1 Transcription in Budding Yeast","year":2009,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; University of Toronto; Terry Fox Foundation; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; Ontario Genomics Institute","keywords":"Biology; Cyclin-dependent kinase; Cyclin-dependent kinase 1; Cell biology; E2F; Retinoblastoma protein; Transcription factor; Histone; Transcription (linguistics); E2F1; Repressor; Psychological repression; Molecular biology; Genetics; Cell cycle; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454597,0.000108847,0.0001747368,0.00006506208,0.00002989238,0.00000628422,0.00006989414,0.0001654773,0.00001522211],"category_scores_gemma":[0.00008545526,0.0001000314,0.00003503218,0.0000550928,0.0001036358,0.000003507879,0.00002434239,0.00007833566,0.000001575068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001442762,"about_ca_system_score_gemma":0.00002642753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004860085,"about_ca_topic_score_gemma":0.00005288487,"domain_scores_codex":[0.9990903,0.0001198611,0.0002245964,0.0002771039,0.00008386547,0.0002042951],"domain_scores_gemma":[0.9996935,0.00001182242,0.00006253614,0.0001276901,0.00005326261,0.0000511718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002887216,0.0001677081,0.001578417,0.00001876984,0.00001613374,0.000001241618,0.00002866148,0.0000139338,0.9941193,0.0001249477,0.00007015796,0.003572027],"study_design_scores_gemma":[0.0009086351,0.0009694454,0.005964823,0.0000258501,0.000008360888,0.000005528717,0.00003531693,0.0001363477,0.9909933,0.0002759819,0.0005656215,0.00011085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967965,0.00212463,0.000177854,0.0002954741,0.0000220112,0.0003019537,0.00007321903,0.000006582203,0.0002018048],"genre_scores_gemma":[0.999047,0.0002106316,0.0001621884,0.0000456939,0.00006181723,0.00002532488,0.0001909363,0.000007751811,0.0002486694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004386405,"threshold_uncertainty_score":0.4079163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427795811724189,"score_gpt":0.2718260086467585,"score_spread":0.2575480505295166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}