{"id":"W2000830616","doi":"10.1111/acel.12274","title":"Increased <scp>L</scp>ipocalin‐2 in the retinal pigment epithelium of <i>Cryba1</i> c<scp>KO</scp> mice is associated with a chronic inflammatory response","year":2014,"lang":"en","type":"article","venue":"Aging Cell","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"National Eye Institute; National Institutes of Health; Research to Prevent Blindness","keywords":"Inflammation; Biology; Chemokine; Retinal pigment epithelium; CCL2; Innate immune system; Macular degeneration; Retinal; Immunology; Pathogenesis; Knockout mouse; Conditional gene knockout; Immune system; Lipocalin; Gliosis; Cell biology; Receptor; Neuroscience; Medicine; Phenotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001898079,0.0005267338,0.0004595941,0.001063331,0.000337041,0.0004742938,0.0002538154,0.000789703,0.003983273],"category_scores_gemma":[0.0001705713,0.0002602569,0.0003786347,0.0003201411,0.0007845482,0.00051391,0.0003124445,0.001458928,0.0005443987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005677476,"about_ca_system_score_gemma":0.0003209298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001940586,"about_ca_topic_score_gemma":0.001860251,"domain_scores_codex":[0.999681,0.00002682148,0.00003581338,0.0001024163,0.00008762877,0.00006628023],"domain_scores_gemma":[0.9994048,0.00004278803,0.0002313576,0.00003826754,0.00004537099,0.0002374452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001018901,0.0000134067,0.0001652013,0.0000228002,0.000005965574,0.00009927606,0.00001013285,0.00001355946,0.9991893,0.00007213202,0.00004269086,0.0002637866],"study_design_scores_gemma":[0.00004168126,0.0001468534,0.02284594,0.00001406755,0.00004503163,0.001916211,0.0001073745,0.0008053317,0.9718331,0.0001348243,0.002092525,0.00001693032],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991725,0.001056387,0.00357651,0.0004754442,0.00007047703,0.00002258639,0.001545069,0.0002813443,0.001247197],"genre_scores_gemma":[0.991368,0.0004959918,0.002356048,0.0001851894,0.00001778292,0.00005036029,0.0008952371,0.0001655986,0.004465893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003983273,"threshold_uncertainty_score":0.01332533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006417106966356773,"score_gpt":0.2258956908855129,"score_spread":0.2194785839191561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}