{"id":"W2000835545","doi":"10.1002/cmdc.201200489","title":"Structure–Activity Relationships of Glucosamine‐Derived Glycerolipids: the Role of the Anomeric Linkage, the Cationic Charge and the Glycero Moiety on the Antitumor Activity","year":2013,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Tokyo Medical and Dental University","keywords":"Chemistry; Stereochemistry; DU145; Moiety; Structure–activity relationship; Glycosidic bond; Amino acid; Cationic polymerization; Biological activity; Biochemistry; LNCaP; Enzyme; In vitro; Cancer cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005793133,0.0003439346,0.0004010649,0.00001568521,0.0008002759,0.00008230223,0.001039576,0.00021169,0.0005814556],"category_scores_gemma":[0.001008461,0.0001376022,0.0002906638,0.0003968228,0.001528593,0.0001330357,0.0002704854,0.0009851839,0.00000892522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007774059,"about_ca_system_score_gemma":0.0001069838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003052323,"about_ca_topic_score_gemma":0.00003082101,"domain_scores_codex":[0.9982168,0.0002516583,0.0003784288,0.0003736092,0.0004475846,0.0003318834],"domain_scores_gemma":[0.9946442,0.002772343,0.0006407333,0.001730087,0.0001511642,0.00006146399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001372962,0.00008640649,0.00184155,0.0001005959,0.0001446419,1.12148e-7,0.001358528,0.00001095134,0.9939858,0.0007067439,0.0001904494,0.00143694],"study_design_scores_gemma":[0.0005790801,0.00000703831,0.01271492,0.00005196437,0.0001182767,0.000009223713,0.001006513,0.001354203,0.982056,0.001571912,0.0003696835,0.0001611675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984318,0.0003889303,0.000004310995,0.006178933,0.00007487456,0.0004803377,0.00007050776,0.00002863238,0.008455454],"genre_scores_gemma":[0.9988279,0.0001292485,0.000006265779,0.0001342314,0.0002232775,0.0001620116,0.000009092422,0.0000315971,0.0004764233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01450983,"threshold_uncertainty_score":0.6366531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173636974269515,"score_gpt":0.1880376562452138,"score_spread":0.1763012865025187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}