{"id":"W2000835545","doi":"10.1002/cmdc.201200489","title":"Structure–Activity Relationships of Glucosamine‐Derived Glycerolipids: the Role of the Anomeric Linkage, the Cationic Charge and the Glycero Moiety on the Antitumor Activity","year":2013,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Tokyo Medical and Dental University","keywords":"Chemistry; Stereochemistry; DU145; Moiety; Structure–activity relationship; Glycosidic bond; Amino acid; Cationic polymerization; Biological activity; Biochemistry; LNCaP; Enzyme; In vitro; Cancer cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001185141,0.0003235352,0.0001931063,0.0002126658,0.00006623291,0.0002442412,0.0001904246,0.0001643341,0.0007137709],"category_scores_gemma":[0.0001310099,0.00008580201,0.000178367,0.000281053,0.0001690158,0.0001917709,0.0001571977,0.0003548035,0.0001778063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622708,"about_ca_system_score_gemma":0.0002938834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006279462,"about_ca_topic_score_gemma":0.001166421,"domain_scores_codex":[0.9999443,0.00001190937,0.000006967137,0.000009348006,0.000013227,0.00001423855],"domain_scores_gemma":[0.999918,0.00001698861,0.00002149615,0.000006612069,0.00001427129,0.00002269004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006850197,0.00007744175,0.0006418127,0.0001067715,0.00001395415,0.00007917388,0.00002241502,0.0008711687,0.9893718,0.0001288564,0.00002688297,0.007974633],"study_design_scores_gemma":[0.00006146039,0.00247716,0.00465574,0.00001180321,0.00005411842,0.0001800943,0.00002696126,0.000661052,0.9892674,0.00006607624,0.002525099,0.00001310705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925983,0.004272512,0.0008792292,0.00005549893,0.00001030097,0.00005448494,0.00039823,0.0000175383,0.001713931],"genre_scores_gemma":[0.9950424,0.00269344,0.001085395,0.00003675752,0.00000507953,0.00002660052,0.0003973886,0.000004523518,0.0007083779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007137709,"threshold_uncertainty_score":0.002387762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173636974269515,"score_gpt":0.1880376562452138,"score_spread":0.1763012865025187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}