{"id":"W2000879435","doi":"10.3747/co.v15i2.210","title":"The Role of DNA Hypermethylation and Demethylation in Cancer and Cancer Therapy","year":2008,"lang":"en","type":"article","venue":"Current Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Methylation; Epigenetics; Biology; Cancer; Cancer epigenetics; Regulation of gene expression; Epigenomics; Cancer research; Genetics; DNA demethylation; RNA-Directed DNA Methylation; Epigenetics of physical exercise; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001253566,0.0003306488,0.0006863559,0.0006606209,0.0003267418,0.0008345477,0.0004963911,0.001123484,0.003542547],"category_scores_gemma":[0.0006942433,0.0001266435,0.00025432,0.0006182218,0.001007663,0.0008231963,0.0007391142,0.001752604,0.0008106371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000926764,"about_ca_system_score_gemma":0.0007068904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004992154,"about_ca_topic_score_gemma":0.0009406588,"domain_scores_codex":[0.9996982,0.000125067,0.00001304503,0.00004022078,0.00009158865,0.00003189412],"domain_scores_gemma":[0.9997529,0.0001165541,0.00003653658,0.00002025923,0.00003527454,0.00003842125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004108821,0.0002877269,0.001427182,0.00202292,0.0001170139,0.0004376329,0.0002330281,0.002213588,0.03042124,0.07661934,0.02305981,0.8627496],"study_design_scores_gemma":[0.0001704554,0.001462359,0.004545617,0.0009192102,0.0001247996,0.002473895,0.0001842557,0.002309105,0.02444411,0.06194,0.901374,0.00005202334],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007232796,0.9602591,0.005357322,0.0111414,0.0009454981,0.0000370513,0.00005854381,0.0000528979,0.01491532],"genre_scores_gemma":[0.1467222,0.8320051,0.005423978,0.004015107,0.002188906,0.00009263355,0.0001038652,0.00001953117,0.009428558],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003542547,"threshold_uncertainty_score":0.01185101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06089327556522165,"score_gpt":0.3734521202117657,"score_spread":0.312558844646544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}