{"id":"W2000879435","doi":"10.3747/co.v15i2.210","title":"The Role of DNA Hypermethylation and Demethylation in Cancer and Cancer Therapy","year":2008,"lang":"en","type":"article","venue":"Current Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; Methylation; Epigenetics; Biology; Cancer; Cancer epigenetics; Regulation of gene expression; Epigenomics; Cancer research; Genetics; DNA demethylation; RNA-Directed DNA Methylation; Epigenetics of physical exercise; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891274,0.00007125885,0.0001021839,0.00003321727,0.00007815439,0.000003639523,0.00004329622,0.00009236339,0.000003306604],"category_scores_gemma":[0.00003899813,0.00005482865,0.00001732416,0.00006124514,0.0001306891,0.000003341103,0.00003244934,0.00006238328,1.369162e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001751115,"about_ca_system_score_gemma":0.00007939562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009390875,"about_ca_topic_score_gemma":0.0003447561,"domain_scores_codex":[0.999423,0.00008567439,0.0001673763,0.0001588693,0.00005778474,0.0001072876],"domain_scores_gemma":[0.9996766,0.0000474846,0.00009659732,0.0000858069,0.00006554338,0.00002789655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00004330397,0.00002673304,0.2573167,0.000003315751,0.000007406756,7.749807e-8,0.0001527021,0.000029014,0.2861022,0.00004886683,0.000008587382,0.4562612],"study_design_scores_gemma":[0.000898727,0.0002698533,0.4697101,0.000009907096,0.000008791429,0.000001520518,0.00007168444,0.0006229322,0.2829672,0.001008737,0.2443196,0.0001108922],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8254766,0.1739364,0.00005115959,0.0001230718,0.0001465293,0.0001240628,0.000004548428,0.00000167331,0.000135917],"genre_scores_gemma":[0.8218384,0.1779376,0.0000506186,0.000009609705,0.00008779563,0.00004192457,0.00001019548,0.000005539487,0.0000182758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4561503,"threshold_uncertainty_score":0.2235847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06089327556522165,"score_gpt":0.3734521202117657,"score_spread":0.312558844646544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}