{"id":"W2000885937","doi":"10.1126/science.1245625","title":"Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer","year":2013,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":826,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Trimer; Gp41; Chemistry; Epitope; Glycoprotein; Biophysics; Antibody; Biology; Biochemistry; Dimer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953045,0.0003140692,0.000479237,0.0001460289,0.0005929318,0.000721637,0.0007143585,0.0006624509,0.002773029],"category_scores_gemma":[0.0003930235,0.0002417071,0.0001798967,0.0003215098,0.0002334123,0.0003819602,0.0002341347,0.001742216,0.0005125575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009050122,"about_ca_system_score_gemma":0.00101563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006047238,"about_ca_topic_score_gemma":0.007206577,"domain_scores_codex":[0.9998479,0.00001593296,0.000005250756,0.00002709729,0.00007882781,0.00002498597],"domain_scores_gemma":[0.9998578,0.00003122732,0.00002212704,0.000006907141,0.00004550412,0.00003638633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002903193,0.001204191,0.01294408,0.000886376,0.0003127777,0.003692179,0.001098029,0.01909445,0.8378486,0.007746933,0.05330364,0.0589655],"study_design_scores_gemma":[0.002921198,0.003077754,0.1397623,0.0003352863,0.0006249259,0.007687871,0.00292569,0.2947279,0.3486611,0.008859484,0.1900706,0.0003458648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665061,0.004910905,0.004781404,0.00220727,0.0002167545,0.0001026539,0.005553897,0.0005102523,0.01521092],"genre_scores_gemma":[0.9417288,0.003474982,0.01761413,0.0009671085,0.0000814852,0.0001092676,0.02467676,0.0001568208,0.01119073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006047238,"threshold_uncertainty_score":0.0120241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277131920286433,"score_gpt":0.2559951065303185,"score_spread":0.2432237873274542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}