{"id":"W2000896070","doi":"10.1074/jbc.m206072200","title":"Both Acidic and Basic Amino Acids in an Amphitropic Enzyme, CTP:Phosphocholine Cytidylyltransferase, Dictate Its Selectivity for Anionic Membranes","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Phosphocholine; Membrane; Phosphatidylcholine; Biochemistry; Membrane protein; Lipid bilayer; Amphiphile; Peptide; Biophysics; Phospholipid; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791757,0.0002787311,0.0001583462,0.00007885548,0.0001137919,0.0002455111,0.0001659782,0.0002936381,0.0005899843],"category_scores_gemma":[0.0002579634,0.0001544791,0.00009749974,0.0001028778,0.0003321749,0.0002602705,0.0002137296,0.000283231,0.0003305026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672924,"about_ca_system_score_gemma":0.0002340798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003693342,"about_ca_topic_score_gemma":0.0006505867,"domain_scores_codex":[0.9999092,0.00001854101,0.000009140749,0.00001628165,0.00003424476,0.00001267716],"domain_scores_gemma":[0.9997959,0.00006788914,0.00004657732,0.00001384126,0.00002532995,0.00005038717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000189973,0.000002493161,0.0001147389,0.000007239806,6.649968e-7,0.00001771732,0.00000511284,0.00002495917,0.9995552,0.00004464066,0.000001734056,0.0002066095],"study_design_scores_gemma":[0.000008767186,0.00007611846,0.002399688,0.000002133384,0.000006038513,0.0002475381,0.00001665424,0.0005965829,0.995908,0.0000760546,0.0006593897,0.000003023243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957746,0.0004015034,0.003191624,0.000049433,0.000005337959,0.00001485298,0.00004815315,0.0000166859,0.0004978974],"genre_scores_gemma":[0.996506,0.0003205166,0.002572381,0.00002223643,0.000003098388,0.00001058149,0.00008656447,0.000009520879,0.0004691383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005899843,"threshold_uncertainty_score":0.001973748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217050373578707,"score_gpt":0.255882712767351,"score_spread":0.2341776754094803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}