{"id":"W2000911009","doi":"10.1593/neo.04478","title":"Therapeutic Efficacy of Adenoviral-Mediated p53 Gene Transfer Is Synergistically Enhanced by Combined Use of Antisense Oligodeoxynucleotide Targeting Clusterin Gene in a Human Bladder Cancer Model","year":2005,"lang":"en","type":"article","venue":"Neoplasia","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Clusterin; Cancer research; Genetic enhancement; Biology; Cisplatin; Bladder cancer; Apoptosis; Pharmacology; Cancer; Chemotherapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001699815,0.0003732665,0.0009215011,0.0002430938,0.00004614454,0.00001178844,0.0001939334,0.0002710751,0.0004689967],"category_scores_gemma":[0.0001494921,0.0003713982,0.0001875615,0.0003413723,0.0002940664,0.0001066182,0.00008067362,0.0002907962,0.00001125762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001313701,"about_ca_system_score_gemma":0.0001877176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001576124,"about_ca_topic_score_gemma":0.000124853,"domain_scores_codex":[0.9972193,0.0001364895,0.001105301,0.0005659619,0.0004165295,0.0005564539],"domain_scores_gemma":[0.9986315,0.0002467602,0.0001691909,0.0005448817,0.0001877052,0.000219954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001566992,0.0009331856,0.002603953,0.0001815336,0.0001879321,0.00004752844,0.001296507,0.00815956,0.9833575,0.00002428193,0.0006918642,0.0009491578],"study_design_scores_gemma":[0.01107725,0.0004976816,0.02389476,0.0002425718,0.0004480277,0.00002461883,0.00004144121,0.08745525,0.875694,0.00002313603,0.000160203,0.0004410364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926676,0.0004444149,0.004959321,0.0005350428,0.00007393746,0.0007772107,0.0003561837,0.00006836488,0.0001178958],"genre_scores_gemma":[0.9946502,0.0002522836,0.003154807,0.001354665,0.00006773834,0.00005812113,0.0001570547,0.00009871367,0.000206357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1076635,"threshold_uncertainty_score":0.9998738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605978760914686,"score_gpt":0.2965058643607085,"score_spread":0.2704460767515617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}