{"id":"W2000945963","doi":"10.1038/cmi.2014.129","title":"Nasopharyngeal cancer-derived microRNA-21 promotes immune suppressive B cells","year":2014,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Immune system; CD8; Cytotoxic T cell; Flow cytometry; microRNA; Biology; Cancer research; Immunology; Blot; Downregulation and upregulation; Nasopharyngeal carcinoma; Cell culture; B cell; Molecular biology; Medicine; Antibody; Internal medicine; Radiation therapy; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002333487,0.0002817959,0.0002693158,0.0002860675,0.0003072582,0.000516613,0.0001590661,0.0002515736,0.002208116],"category_scores_gemma":[0.0003188617,0.0001798986,0.0002810854,0.0001374529,0.0002797735,0.0002054166,0.0003850183,0.0007055273,0.0005901277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003891764,"about_ca_system_score_gemma":0.0004776255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009146394,"about_ca_topic_score_gemma":0.001660165,"domain_scores_codex":[0.9997299,0.00005298533,0.00001964991,0.00004148547,0.00008317632,0.00007268854],"domain_scores_gemma":[0.9998934,0.00002183304,0.0000199008,0.00001406209,0.00001728436,0.00003343424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003895149,0.00005203274,0.001463374,0.00006474221,0.0000155378,0.0002999534,0.00005084544,0.0001189545,0.991458,0.0003454599,0.0004680433,0.005273543],"study_design_scores_gemma":[0.0000859724,0.0006017702,0.02417114,0.00001303964,0.00008900227,0.001064263,0.0002202689,0.002031215,0.95442,0.0003572736,0.01693303,0.00001301312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847024,0.003793163,0.003156437,0.0003679341,0.0002564031,0.00008290711,0.000412834,0.0002381016,0.006989833],"genre_scores_gemma":[0.9953879,0.0007464304,0.0008682294,0.0001111182,0.00003083414,0.00003795338,0.0002092093,0.00002861278,0.002579805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002208116,"threshold_uncertainty_score":0.007386863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004456615109875418,"score_gpt":0.2117275247007404,"score_spread":0.207270909590865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}