{"id":"W2000948510","doi":"10.1074/jbc.m114.573576","title":"Wilms Tumor Suppressor, WT1, Suppresses Epigenetic Silencing of the β-Catenin Gene","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cancer research; Gene silencing; Epigenetics; Wilms' tumor; Progenitor cell; Wnt signaling pathway; Stem cell; Cell biology; Molecular biology; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008599491,0.0003100543,0.0001297451,0.0002152,0.0001487305,0.0001738779,0.0001225322,0.0001374242,0.001187118],"category_scores_gemma":[0.00008935956,0.00009970986,0.0001236176,0.0001073062,0.0001729531,0.00008681929,0.0001354615,0.000296507,0.0003414719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002065069,"about_ca_system_score_gemma":0.0002399132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005382836,"about_ca_topic_score_gemma":0.0009813613,"domain_scores_codex":[0.9999373,0.000006128442,0.000005502754,0.00001304133,0.00002793549,0.00001018459],"domain_scores_gemma":[0.9999534,0.000005858271,0.00001840726,0.000004222597,0.000003924387,0.0000141992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004072486,0.00001382871,0.0002591123,0.00003526241,0.000003038052,0.00003977126,0.000007592868,0.00004697888,0.9978892,0.0001061334,0.00004888348,0.001509449],"study_design_scores_gemma":[0.00001362729,0.0001275473,0.004738775,0.000004809043,0.00001122481,0.0003250202,0.00001638608,0.0005067901,0.9910489,0.0000428421,0.003162128,0.000001910664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992304,0.003025717,0.002086157,0.000135101,0.00004565021,0.00002747915,0.0004793057,0.0002387088,0.001657769],"genre_scores_gemma":[0.994881,0.001298022,0.0006206172,0.00003214503,0.000009295209,0.00001778593,0.0004369245,0.00001856072,0.00268573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187118,"threshold_uncertainty_score":0.003971279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008577216661624374,"score_gpt":0.2147645936780623,"score_spread":0.206187377016438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}