{"id":"W2000962968","doi":"10.1021/bi015967+","title":"Calnexin Deficiency and Endoplasmic Reticulum Stress-Induced Apoptosis","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Calnexin; Endoplasmic reticulum; Unfolded protein response; Apoptosis; Cell biology; Cleavage (geology); Immunoprecipitation; Biology; Thapsigargin; Calreticulin; Chemistry; Biochemistry; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00005547514,0.0002672276,0.0001714044,0.00002900975,0.000130665,0.000054317,0.0002123742,0.0002310831,0.0001570089],"category_scores_gemma":[0.0001627757,0.0002600889,0.0001037592,0.000091205,0.0001455381,0.000004714376,0.0001554865,0.0001211102,0.00002865899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001358926,"about_ca_system_score_gemma":0.00003105969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002203062,"about_ca_topic_score_gemma":0.000003341427,"domain_scores_codex":[0.998539,0.00002761658,0.0002363159,0.0006150407,0.0001899967,0.0003919781],"domain_scores_gemma":[0.9990484,0.00001493654,0.00008525443,0.0005150604,0.00005748831,0.0002789158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002319766,0.0001491491,0.007205973,0.00009468594,0.00002416411,0.000008191233,0.00002733673,0.000003526804,0.9872174,0.00004102724,0.004133334,0.001071987],"study_design_scores_gemma":[0.0006328265,0.00009710859,0.000501227,0.00003123567,0.00003532747,0.00004019913,0.000143791,0.0002066127,0.9969292,0.00001897014,0.001017621,0.0003458248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864485,0.002663243,0.00003128166,0.0001696687,0.0001070445,0.0001178559,0.00008807641,0.00003407605,0.01034022],"genre_scores_gemma":[0.9970832,0.000787607,0.0002120055,0.0001550736,0.000195555,0.00003604827,0.00009340438,0.00002928933,0.00140775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063474,"threshold_uncertainty_score":0.9999852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00987339689548061,"score_gpt":0.2155480755945976,"score_spread":0.205674678699117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}