{"id":"W2000970939","doi":"10.3389/fgene.2014.00212","title":"Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons","year":2014,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Biology; RNA interference; Insulin receptor; Cell biology; Signal transduction; Mechanosensation; Insulin; TOR signaling; Proteotoxicity; Neuron; Neuroscience; Protein aggregation; Endocrinology; Receptor; Insulin resistance; RNA; Genetics; Gene; Ion channel","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009044437,0.0003589874,0.0001706832,0.0001919312,0.0001309696,0.0002033791,0.0001813258,0.0002932794,0.0005902866],"category_scores_gemma":[0.00005812918,0.0001489569,0.0002249798,0.0000853732,0.0001834129,0.0002648858,0.0002318957,0.0004441553,0.0001003293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967182,"about_ca_system_score_gemma":0.000175697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007951906,"about_ca_topic_score_gemma":0.001480382,"domain_scores_codex":[0.9999229,0.000005457948,0.00000954207,0.00002730869,0.00001845488,0.00001637162],"domain_scores_gemma":[0.9999293,0.00000423954,0.0000252003,0.000006570137,0.000009883479,0.00002486965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006131334,0.000008271934,0.000203929,0.00001546996,0.00000222603,0.00002529921,0.000008085279,0.00001783974,0.9993159,0.00001726207,0.000006519943,0.0003178997],"study_design_scores_gemma":[0.00001886779,0.0004554476,0.0464208,0.0000128371,0.00003131952,0.0002470103,0.0000648097,0.0007517172,0.9508631,0.0001042458,0.001016998,0.00001296938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979705,0.0008130036,0.0006161024,0.00003399408,0.00001461503,0.000008081327,0.0001792968,0.00002415337,0.0003400973],"genre_scores_gemma":[0.9960808,0.0008786324,0.00109251,0.00005132442,0.000004801255,0.00003161095,0.0002472064,0.00001341654,0.0015997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007951906,"threshold_uncertainty_score":0.002152801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008987437266426316,"score_gpt":0.2242129931417687,"score_spread":0.2152255558753424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}