{"id":"W2000972592","doi":"10.1016/j.imlet.2006.05.003","title":"Prolonged costimulation is required for naive T cell activation","year":2006,"lang":"en","type":"article","venue":"Immunology Letters","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Kidney Foundation of Canada","keywords":"CD86; CD80; CD28; T cell; Naive T cell; IL-2 receptor; Cell biology; Antigen-presenting cell; Interleukin 21; Biology; CD40; Immunology; T-cell receptor; Chemistry; Cytotoxic T cell; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000230836,0.0004865711,0.000538398,0.0002256626,0.0002831735,0.0009954714,0.0003740414,0.000599583,0.003295644],"category_scores_gemma":[0.0005697241,0.0002971573,0.0003688828,0.0001696649,0.0002926566,0.0006318426,0.0005955251,0.00198721,0.001333823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007806497,"about_ca_system_score_gemma":0.0003626499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003959217,"about_ca_topic_score_gemma":0.0006985302,"domain_scores_codex":[0.9995962,0.00005196237,0.00003822745,0.00006474454,0.00008570978,0.0001631963],"domain_scores_gemma":[0.9992854,0.0001309097,0.0001334992,0.0001413695,0.00008320422,0.0002256697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003364409,0.00002467531,0.0001615231,0.00002513858,0.000005257771,0.00005541011,0.000007349006,0.00003903879,0.9982224,0.0001296331,0.0001057154,0.0008874144],"study_design_scores_gemma":[0.0001510299,0.0007082993,0.02859198,0.00002736622,0.00004155346,0.0008762284,0.00009030402,0.001304189,0.9603268,0.0004065672,0.007455737,0.00002008047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902266,0.004252535,0.002450862,0.0003798736,0.0001885262,0.00004223189,0.00060213,0.0001993464,0.001657954],"genre_scores_gemma":[0.9952801,0.0005178374,0.001397308,0.0001769424,0.00007190142,0.00005265033,0.001033415,0.00005375834,0.001416074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003295644,"threshold_uncertainty_score":0.01102495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101734453766879,"score_gpt":0.220817419892753,"score_spread":0.2098000753550842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}