{"id":"W2000972592","doi":"10.1016/j.imlet.2006.05.003","title":"Prolonged costimulation is required for naive T cell activation","year":2006,"lang":"en","type":"article","venue":"Immunology Letters","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Kidney Foundation of Canada","keywords":"CD86; CD80; CD28; T cell; Naive T cell; IL-2 receptor; Cell biology; Antigen-presenting cell; Interleukin 21; Biology; CD40; Immunology; T-cell receptor; Chemistry; Cytotoxic T cell; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001993097,0.000352638,0.0004290515,0.0002610561,0.0004634822,0.00002354188,0.0003550832,0.0006657638,0.0003242925],"category_scores_gemma":[0.00004305098,0.0003487438,0.0001951593,0.0001883211,0.0005144111,0.0002262668,0.00008244408,0.0004224154,0.0008266486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001310853,"about_ca_system_score_gemma":0.00005176499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002694654,"about_ca_topic_score_gemma":0.000009117606,"domain_scores_codex":[0.99784,0.0002298858,0.0005372644,0.0005972611,0.00004178276,0.0007537861],"domain_scores_gemma":[0.9986783,0.000341419,0.00034847,0.0004870432,0.0001325511,0.00001224051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008406721,0.0002138765,0.001068783,0.00001704454,0.000196758,0.000002876541,0.0002558911,0.00004482464,0.9636019,0.0004576572,0.03216054,0.001139174],"study_design_scores_gemma":[0.004628929,0.0003854585,0.00326568,0.00001681202,0.00007634449,0.00003324924,0.0000748565,0.00001968422,0.9167691,0.0005996397,0.07375527,0.0003750036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983732,0.001400273,0.003830811,0.007320776,0.001529592,0.001003101,0.00004567078,0.000259816,0.0008779811],"genre_scores_gemma":[0.9917946,0.00002129291,0.0003964095,0.00248904,0.0001167737,0.0002276653,0.0008861368,0.00004873113,0.004019372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04683283,"threshold_uncertainty_score":0.9999513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101734453766879,"score_gpt":0.220817419892753,"score_spread":0.2098000753550842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}