{"id":"W2000999460","doi":"10.1038/labinvest.3700500","title":"Pronounced cytosolic aggregation of cellular prion protein in pancreatic β-cells in response to hyperglycemia","year":2006,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Simon Fraser University","funders":"Canadian Institutes of Health Research; Simon Fraser University; Canadian Diabetes Association","keywords":"Endocrinology; Internal medicine; Cytosol; Pancreas; Diabetes mellitus; Pancreatic islets; Islet; Homeostasis; Glucose homeostasis; Beta cell; Biology; Enteroendocrine cell; In vivo; Endocrine system; In vitro; Cell; Insulin; Hormone; Medicine; Insulin resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004636874,0.0001253011,0.0001389608,0.0001492257,0.00002538181,0.00001485004,0.0001017588,0.0001330063,0.000005242084],"category_scores_gemma":[0.0002223701,0.0001395978,0.00002625719,0.0004926578,0.0000459257,0.00001449864,0.00003253025,0.00006765526,0.000006391502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007013301,"about_ca_system_score_gemma":0.0002735092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001752532,"about_ca_topic_score_gemma":0.0001857932,"domain_scores_codex":[0.9987782,0.0002725066,0.0003513313,0.0002792735,0.0001462393,0.0001724056],"domain_scores_gemma":[0.9994464,0.00001262643,0.0001371654,0.0002438385,0.00009597651,0.00006397872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004240588,0.00003975684,0.02068616,0.000050884,0.000002512753,0.000002239686,0.0000799558,0.0008076882,0.9774131,0.0001124041,0.0000378817,0.0003433246],"study_design_scores_gemma":[0.0006482895,0.0001622148,0.03212602,0.0001614635,0.000004414836,2.179082e-7,0.00003149433,0.0001455983,0.9651791,0.0004085464,0.0009814792,0.0001511893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982145,0.0005456702,0.0002209153,0.0001404295,0.00002963029,0.0007928513,0.0000232879,0.00001053132,0.00002216452],"genre_scores_gemma":[0.9978839,0.00001936938,0.001622397,0.0001026936,0.00006181385,0.0001622365,0.00008927434,0.00001704755,0.00004122325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01223406,"threshold_uncertainty_score":0.5692632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005462810331283531,"score_gpt":0.2107424429349656,"score_spread":0.205279632603682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}