{"id":"W2000999642","doi":"10.1016/j.immuni.2009.04.011","title":"Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2","year":2009,"lang":"en","type":"article","venue":"Immunity","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":338,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"NOD2; Nod; Biology; Cell biology; Muramyl dipeptide; Signal transduction; Inhibitor of apoptosis; Innate immune system; Ubiquitin; Chemokine; Cancer research; Ubiquitin ligase; Apoptosis; Immunology; Inflammation; In vivo; Immune system; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003321226,0.0004996727,0.0004283205,0.0003968467,0.0004443952,0.001186932,0.0004394624,0.0003972483,0.002114755],"category_scores_gemma":[0.000659312,0.00028754,0.000279018,0.0002586882,0.0003359282,0.0006233586,0.0004924393,0.001470713,0.0007526733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001033949,"about_ca_system_score_gemma":0.0004886918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004947315,"about_ca_topic_score_gemma":0.0006602332,"domain_scores_codex":[0.9994605,0.00006396906,0.00004138508,0.00008915423,0.0001637434,0.0001813094],"domain_scores_gemma":[0.9993475,0.00008078895,0.0002360996,0.00007485893,0.0001031456,0.0001575705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008370006,0.00004567844,0.001352876,0.00008310094,0.0000174194,0.0001716838,0.00002256899,0.0002336031,0.9921943,0.0008266853,0.0003803556,0.003834633],"study_design_scores_gemma":[0.0001137368,0.0002069622,0.02802204,0.00001690748,0.00003563649,0.001546851,0.00009951749,0.003256511,0.9515809,0.0005098431,0.01458727,0.00002379667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745737,0.01209632,0.006084138,0.0005742027,0.0001609835,0.00004574343,0.00102506,0.0002137542,0.005226022],"genre_scores_gemma":[0.9910383,0.001403132,0.001903659,0.00009835002,0.00002731014,0.00005549547,0.001415675,0.0000327388,0.004025462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002114755,"threshold_uncertainty_score":0.007501841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899361497205697,"score_gpt":0.2359010077567162,"score_spread":0.2169073927846592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}