{"id":"W2001023177","doi":"10.1371/journal.pone.0039908","title":"Extracellular IgC2 Constant Domains of CEACAMs Mediate PI3K Sensitivity during Uptake of Pathogens","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; BC Cancer Agency; University of Toronto; Deutsche Forschungsgemeinschaft; Cancer Research UK","keywords":"Internalization; Phosphatidylinositol; Endocytosis; Cell biology; Biology; Receptor; Endosome; PI3K/AKT/mTOR pathway; Signal transduction; Biochemistry; Intracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002817782,0.0001064188,0.0003529511,0.00002694606,0.0000371806,0.000001588435,0.00004038633,0.00008063352,0.0001461892],"category_scores_gemma":[0.0001363239,0.00009941008,0.00007774186,0.000134421,0.0001754622,0.0000428477,0.0000266526,0.0001757968,0.00001493113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002724842,"about_ca_system_score_gemma":0.0000310396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002056842,"about_ca_topic_score_gemma":2.593899e-7,"domain_scores_codex":[0.9989509,0.00002697284,0.0003337686,0.0001359058,0.0003026651,0.0002498092],"domain_scores_gemma":[0.9991487,0.0001000966,0.0001234001,0.0002907701,0.0000926077,0.0002444239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007110182,0.002131495,0.01105295,0.0006073501,0.0001692184,0.00001828286,0.0001629878,9.081365e-7,0.9850661,0.0005884371,0.000005267855,0.0001259078],"study_design_scores_gemma":[0.0007481934,0.00002559047,0.01711778,0.0001610592,0.0004491923,0.00002914674,0.000078728,0.0001318366,0.9810361,0.00002544918,0.0001117351,0.00008521849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963135,0.0009725117,0.00009660426,0.0002349597,0.00001286351,0.0002562274,0.00009877793,0.00003363582,0.001980948],"genre_scores_gemma":[0.9972479,0.0001387292,0.002095755,0.00001925065,0.0001719042,0.00001378905,0.0000220282,0.00001510854,0.0002755385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006064835,"threshold_uncertainty_score":0.4053825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05916855421783156,"score_gpt":0.2730992757457346,"score_spread":0.213930721527903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}