{"id":"W2001045107","doi":"10.1074/jbc.m104064200","title":"Inhibitory Specificity and Potency of proSAAS-derived Peptides toward Proprotein Convertase 1","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital","funders":"Medical Research Council; Canadian Institutes of Health Research; Government of Canada","keywords":"Stereochemistry; Circular dichroism; Chemistry; Prohormone convertase; Amino acid; Peptide; Potency; Lysine; Peptide sequence; Biochemistry; Prohormone; In vitro; Hormone; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182581,0.0004273939,0.0002199601,0.0001443523,0.00008307812,0.0002539198,0.0002190445,0.0001744515,0.0009784097],"category_scores_gemma":[0.0002501787,0.00009806255,0.0001893681,0.0001154807,0.0001655138,0.0001124869,0.0001092311,0.0004401653,0.0003936425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001701356,"about_ca_system_score_gemma":0.0001846898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007212517,"about_ca_topic_score_gemma":0.0005386234,"domain_scores_codex":[0.9997523,0.00005394647,0.00002791898,0.00003447277,0.00007250877,0.00005885092],"domain_scores_gemma":[0.9998299,0.00005591585,0.00003694367,0.00001333087,0.00002473921,0.00003910336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002518905,0.00003690281,0.0002773114,0.00004448078,0.00001045617,0.00003292098,0.00001252778,0.0001875175,0.9978187,0.00004016868,0.00002208484,0.001264983],"study_design_scores_gemma":[0.000008985294,0.0005839854,0.002068905,0.000003614557,0.00001209429,0.0001515174,0.000009987511,0.0006041895,0.9961122,0.00001028874,0.000430068,0.000004112821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961997,0.001795258,0.0005716957,0.00001741165,0.00001026864,0.0000106987,0.0001485728,0.00001293695,0.001233551],"genre_scores_gemma":[0.9969676,0.000969105,0.0006651944,0.00002356833,0.00001052985,0.00001171943,0.0003970964,0.000006349914,0.0009487263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009784097,"threshold_uncertainty_score":0.003273129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01953501239095713,"score_gpt":0.2221369696350274,"score_spread":0.2026019572440703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}