{"id":"W2001063978","doi":"10.1074/jbc.m701279200","title":"Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Intracellular; Sphingosine; Extracellular; Sphingosine-1-phosphate; Cell biology; Sphingosine kinase; Sphingosine kinase 1; Biology; Chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009907874,0.0001322008,0.0002745324,0.00003550365,0.00003061084,0.00001015715,0.0002094132,0.0002516269,0.0000601071],"category_scores_gemma":[0.0001415909,0.0001031863,0.0001466395,0.00008619146,0.00007832155,0.000005338421,0.00005062867,0.000203146,3.667313e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001722848,"about_ca_system_score_gemma":0.00003635142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000057464,"about_ca_topic_score_gemma":0.000001273052,"domain_scores_codex":[0.9987723,0.00002962688,0.0006763121,0.0001650467,0.0001424021,0.0002143513],"domain_scores_gemma":[0.9992222,0.00002004909,0.0004129346,0.0001337396,0.0001215978,0.00008947572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001383882,0.0001043626,0.003232466,0.00002340578,0.00002286769,0.000025657,0.00002390343,0.0001493638,0.9957489,0.00001641033,0.00009728241,0.0004169807],"study_design_scores_gemma":[0.000817007,0.0001132949,0.0008728523,0.0000229759,0.00001323234,0.00003789229,0.00003920993,0.00003767939,0.9959567,0.00002776382,0.001948459,0.0001129086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944252,0.002546829,0.002557196,0.00001514233,0.0001654643,0.00004788466,0.000006804716,0.000002531255,0.0002329991],"genre_scores_gemma":[0.9971848,0.0003143451,0.0009670403,0.00005207366,0.001379924,6.219819e-7,0.00002397359,0.000008942283,0.00006831631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002759614,"threshold_uncertainty_score":0.4207814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01922148029068339,"score_gpt":0.2615852779007407,"score_spread":0.2423637976100573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}