{"id":"W2001069949","doi":"10.1016/s0014-5793(02)02610-8","title":"Zinc is required for structural stability of the C‐terminus of archaeal translation initiation factor aIF2β","year":2002,"lang":"en","type":"article","venue":"FEBS Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; McGill University","funders":"","keywords":"Zinc finger; Eukaryotic translation; Translation (biology); Start codon; Initiation factor; Eukaryotic initiation factor; EIF4A1; Eukaryotic translation initiation factor 4 gamma; Chemistry; Biology; Cell biology; Genetics; Computational biology; Biochemistry; Messenger RNA; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007644557,0.0000779928,0.0001011451,0.00001502127,0.00003780266,0.000003824684,0.0001243714,0.00007046859,0.00005439404],"category_scores_gemma":[0.00003823256,0.00005984273,0.0001201854,0.0000344743,0.00006689567,0.000005313292,0.00001586368,0.00002470475,3.883589e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006972996,"about_ca_system_score_gemma":0.000008833545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009703302,"about_ca_topic_score_gemma":0.000008019489,"domain_scores_codex":[0.9993888,0.00006096638,0.0001960519,0.0001446594,0.0001048091,0.0001046908],"domain_scores_gemma":[0.9995572,0.0000234637,0.0001328944,0.0002321595,0.00003696244,0.00001733775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005362062,0.000007675501,0.0008242696,0.00004098852,0.00001610451,7.01806e-8,0.0004412913,0.000003577488,0.9913116,0.00001394104,0.0001099267,0.007176943],"study_design_scores_gemma":[0.0002969634,0.00009298294,0.003703495,0.000009382004,0.00001192392,0.000001202058,0.00001613529,0.0001166837,0.9949496,0.0001231856,0.0006108825,0.00006749927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941215,0.00008920558,0.00392054,0.001203808,0.000111376,0.0003430327,0.0001670835,0.000002974377,0.00004051241],"genre_scores_gemma":[0.9984302,0.00000708639,0.001042817,0.0003956267,0.00006620913,0.00001608451,0.00002109368,0.000008521712,0.00001239222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007109444,"threshold_uncertainty_score":0.2440316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209043955317396,"score_gpt":0.2519570746431763,"score_spread":0.2098666350900024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}