{"id":"W2001101692","doi":"10.1373/clinchem.2010.161141","title":"Analysis of Glycosaminoglycans in Cerebrospinal Fluid from Patients with Mucopolysaccharidoses by Isotope-Dilution Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry","year":2011,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Chromatography; Hurler syndrome; Selected reaction monitoring; Cerebrospinal fluid; Enzyme replacement therapy; Electrospray ionization; Glycosaminoglycan; Isotope dilution; Liquid chromatography–mass spectrometry; Tandem mass spectrometry; High-performance liquid chromatography; Mass spectrometry; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004306536,0.0008679219,0.0004597277,0.001725738,0.0004592781,0.0006003973,0.0003641409,0.0005476129,0.0003947401],"category_scores_gemma":[0.0008991298,0.0001411283,0.0002658488,0.0007885965,0.0003867298,0.0002017447,0.0002586418,0.0004903909,0.0002331841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376506,"about_ca_system_score_gemma":0.0004732643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001587019,"about_ca_topic_score_gemma":0.001581956,"domain_scores_codex":[0.9994569,0.00006333358,0.00007567577,0.0001159302,0.0002364619,0.00005164918],"domain_scores_gemma":[0.9997273,0.00005068729,0.00007246804,0.0000129333,0.00009399263,0.00004256542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001340649,0.0003334155,0.2599121,0.0003852739,0.0003148575,0.004088637,0.0007228145,0.0003671803,0.682708,0.0001615391,0.001011186,0.0486544],"study_design_scores_gemma":[0.0001235444,0.00194249,0.5118216,0.0002251102,0.0003908363,0.02859872,0.001053849,0.004834307,0.4414276,0.000377879,0.009111432,0.0000926038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883333,0.005073244,0.003616121,0.0001641687,0.00007178471,0.00010606,0.001293236,0.0002108249,0.001131295],"genre_scores_gemma":[0.9851637,0.002049001,0.01060294,0.0003182337,0.00005149377,0.00008656097,0.001286329,0.00002527712,0.0004165883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001725738,"threshold_uncertainty_score":0.003155589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02467341042869365,"score_gpt":0.2915064603036127,"score_spread":0.2668330498749191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}