{"id":"W2001142914","doi":"10.1016/j.ccr.2009.12.045","title":"PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia","year":2010,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research","funders":"Biotechnology and Biological Sciences Research Council; Science and Technology Commission of Shanghai Municipality; Ministry of Science and Technology of the People's Republic of China; Chinese Academy of Sciences","keywords":"Acute promyelocytic leukemia; Transactivation; Promyelocytic leukemia protein; Promoter; Retinoic acid; Cancer research; Gene; Biology; Leukemia; Molecular biology; Transcription factor; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200451,0.000215499,0.0002014697,0.00003186332,0.00009094035,0.00004298842,0.0001778045,0.0002628412,0.00006560014],"category_scores_gemma":[0.00004832168,0.0002006566,0.00005098776,0.00007767931,0.0001953263,0.000007247867,0.0001060686,0.0002818225,0.000005016914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000066485,"about_ca_system_score_gemma":0.0004741791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001416592,"about_ca_topic_score_gemma":0.0005174762,"domain_scores_codex":[0.9988211,0.00003661352,0.0002195416,0.0004828408,0.00009496643,0.000344936],"domain_scores_gemma":[0.9993656,0.00001849139,0.00009792245,0.0003139981,0.0000877795,0.0001161997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009143321,0.00002149427,0.007221702,0.0001132018,0.00003194582,0.00005880291,0.0002867503,0.00001087506,0.9894211,0.00005876999,0.001291336,0.001392554],"study_design_scores_gemma":[0.00137256,0.0002055121,0.0008242238,0.00004748839,0.00004926745,0.0000813485,0.0002314486,0.0002530342,0.9495443,0.0002066437,0.04678643,0.0003978129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886094,0.006719812,0.00006610064,0.0002398323,0.0002036484,0.0003066622,0.0000175334,0.0000197227,0.003817279],"genre_scores_gemma":[0.9951039,0.001004148,0.0007897583,0.0002390396,0.0002158671,0.0001084959,0.00008232737,0.00003505508,0.002421434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04549509,"threshold_uncertainty_score":0.8182539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008664573499028801,"score_gpt":0.2463373529415542,"score_spread":0.2376727794425254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}