{"id":"W2001142914","doi":"10.1016/j.ccr.2009.12.045","title":"PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia","year":2010,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research","funders":"Biotechnology and Biological Sciences Research Council; Science and Technology Commission of Shanghai Municipality; Ministry of Science and Technology of the People's Republic of China; Chinese Academy of Sciences","keywords":"Acute promyelocytic leukemia; Transactivation; Promyelocytic leukemia protein; Promoter; Retinoic acid; Cancer research; Gene; Biology; Leukemia; Molecular biology; Transcription factor; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000295542,0.0003083851,0.0003581968,0.0003322582,0.0004304992,0.0005051079,0.000363544,0.0002583572,0.002082852],"category_scores_gemma":[0.0003312862,0.0003813563,0.0002576104,0.0001918529,0.0003823491,0.0002428994,0.0003440031,0.0007234725,0.001208815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005207771,"about_ca_system_score_gemma":0.0003866146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007453688,"about_ca_topic_score_gemma":0.001459933,"domain_scores_codex":[0.999759,0.0000491376,0.00001959454,0.00005245448,0.00006401269,0.00005581594],"domain_scores_gemma":[0.9997771,0.0000569584,0.00004944792,0.00003311476,0.0000223043,0.00006104314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002870859,0.00002731086,0.0001831447,0.00003447096,0.000004026931,0.00005199711,0.00002523225,0.0001892834,0.9966966,0.0002666433,0.00009966507,0.002134505],"study_design_scores_gemma":[0.00004665109,0.000138575,0.002166374,0.000007752533,0.00001251917,0.0002363922,0.00005310282,0.0009257536,0.9939932,0.0001446835,0.002270897,0.000003964004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855371,0.003271317,0.006922872,0.0002656318,0.00008161891,0.0000428383,0.0004717148,0.0003183121,0.003088437],"genre_scores_gemma":[0.9943189,0.0005192135,0.002136497,0.00006036659,0.00001286081,0.00001723777,0.0003749683,0.00004404703,0.002515835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002082852,"threshold_uncertainty_score":0.006967843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008664573499028801,"score_gpt":0.2463373529415542,"score_spread":0.2376727794425254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}