{"id":"W2001158990","doi":"10.1074/jbc.m110.115311","title":"Vascular Endothelial Growth Factor Receptor-2 Activates ADP-ribosylation Factor 1 to Promote Endothelial Nitric-oxide Synthase Activation and Nitric Oxide Release from Endothelial Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Cell biology; Angiogenesis; Protein kinase B; Enos; Vascular endothelial growth factor; Vascular endothelial growth factor A; Nitric oxide; Vascular endothelial growth factor B; Signal transduction; PI3K/AKT/mTOR pathway; Nitric Oxide Synthase Type III; Vascular endothelial growth factor C; Endothelial stem cell; Chemistry; Vascular permeability; Biology; Nitric oxide synthase; Cancer research; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013364,0.0004649442,0.0001895185,0.0002123665,0.0001578322,0.0002639065,0.0001300269,0.0002582355,0.001642433],"category_scores_gemma":[0.0001148794,0.0001448279,0.0003250111,0.0001669588,0.0001371913,0.0001887179,0.0001823391,0.0005362802,0.0004576602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003150309,"about_ca_system_score_gemma":0.0001620396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790929,"about_ca_topic_score_gemma":0.0006879675,"domain_scores_codex":[0.9998747,0.0000252742,0.00000588874,0.00002589628,0.00003501926,0.00003320708],"domain_scores_gemma":[0.9999582,0.000007695817,0.00001195845,0.000004355004,0.000005605413,0.00001226024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001428494,0.00006500204,0.0002558409,0.0000819195,0.00001199007,0.0001257309,0.00001669785,0.0001216508,0.9950594,0.0004228257,0.0003299996,0.003366097],"study_design_scores_gemma":[0.00008868901,0.0005629839,0.01386738,0.00001793365,0.00003301316,0.0009141155,0.00003585138,0.004529909,0.9498118,0.0005312396,0.02958798,0.00001921521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580141,0.01861966,0.01252129,0.0006801656,0.0004406448,0.0001014454,0.0007803441,0.0003598299,0.008482669],"genre_scores_gemma":[0.9860514,0.004229689,0.002963361,0.000152601,0.00004807312,0.00006297165,0.000688752,0.00001565806,0.005787447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642433,"threshold_uncertainty_score":0.005494475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154896821687778,"score_gpt":0.2443072418061623,"score_spread":0.2288175596373845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}