{"id":"W2001179836","doi":"10.1111/j.1462-2920.2007.01367.x","title":"The natural furanone ( <i>5Z</i> )‐4‐bromo‐5‐(bromomethylene)‐3‐butyl‐2( <i>5H</i> )‐furanone disrupts quorum sensing‐regulated gene expression in <i>Vibrio harveyi</i> by decreasing the DNA‐binding activity of the transcriptional regulator protein luxR","year":2007,"lang":"en","type":"article","venue":"Environmental Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Biomedical Imaging and Bioengineering","keywords":"Vibrio harveyi; Quorum sensing; Biology; Mutant; Gene; Bioluminescence; Promoter; Autoinducer; DNA; Virulence; Microbiology; Biochemistry; Gene expression; Genetics; Vibrio; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008887631,0.0004450436,0.0003719523,0.00004876117,0.0006292493,0.00004756032,0.0004688472,0.0004411139,0.00001474621],"category_scores_gemma":[0.00004320604,0.0002694994,0.0002712262,0.0001972953,0.001027882,0.00002562875,0.0003385555,0.0004404704,0.000005702884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001219006,"about_ca_system_score_gemma":0.00005095839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000550882,"about_ca_topic_score_gemma":0.0001915286,"domain_scores_codex":[0.9971155,0.0006034577,0.0006165025,0.0006777666,0.0001823584,0.0008044213],"domain_scores_gemma":[0.9987187,0.000104457,0.0003903132,0.0006762117,0.00001829581,0.00009205862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007558478,0.000130011,0.0006677353,0.000009310767,0.00006290396,0.000004189157,0.0000864617,0.000004804595,0.9956806,0.000005270517,0.0001986815,0.002394205],"study_design_scores_gemma":[0.001099756,0.0001190409,0.01348334,0.00006673786,0.00002621073,0.0001955763,0.0001037269,0.00000890173,0.9731644,0.000007432667,0.0113913,0.000333568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961173,0.001440835,0.00009464063,0.0006328035,0.0006263254,0.0007782491,0.0002662851,0.00001402004,0.00002956841],"genre_scores_gemma":[0.9978355,0.0001091861,0.0006308157,0.0002436894,0.0001666569,0.000007411539,0.0003850493,0.00005501648,0.0005667069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02251617,"threshold_uncertainty_score":0.9999757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003320695560606591,"score_gpt":0.1837284673258881,"score_spread":0.1804077717652815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}