{"id":"W2001179836","doi":"10.1111/j.1462-2920.2007.01367.x","title":"The natural furanone ( <i>5Z</i> )‐4‐bromo‐5‐(bromomethylene)‐3‐butyl‐2( <i>5H</i> )‐furanone disrupts quorum sensing‐regulated gene expression in <i>Vibrio harveyi</i> by decreasing the DNA‐binding activity of the transcriptional regulator protein luxR","year":2007,"lang":"en","type":"article","venue":"Environmental Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Biomedical Imaging and Bioengineering","keywords":"Vibrio harveyi; Quorum sensing; Biology; Mutant; Gene; Bioluminescence; Promoter; Autoinducer; DNA; Virulence; Microbiology; Biochemistry; Gene expression; Genetics; Vibrio; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009681738,0.0002289114,0.0001977452,0.00008471518,0.00008157492,0.0001652978,0.0001596331,0.0002265985,0.0009180151],"category_scores_gemma":[0.00007802832,0.00008623445,0.0001894259,0.00006092467,0.0001800295,0.0001398942,0.0001191946,0.0003035899,0.0001960684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445017,"about_ca_system_score_gemma":0.0002161575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005382759,"about_ca_topic_score_gemma":0.0006666178,"domain_scores_codex":[0.9998944,0.00001943392,0.000007441166,0.00002442307,0.00002478923,0.00002953433],"domain_scores_gemma":[0.9999344,0.0000137737,0.0000224681,0.000007753063,0.000007312707,0.00001430321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003402962,0.000005470716,0.0000437786,0.00001055929,0.000001278229,0.00000728624,0.000002144156,0.0000263514,0.9996666,0.00002846149,0.000002826186,0.0001711893],"study_design_scores_gemma":[0.000008191316,0.0002896002,0.001057789,0.000001428175,0.000004063524,0.00005697527,0.000007769107,0.0001433286,0.9978097,0.00001356201,0.0006052789,0.000002308559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963109,0.000862502,0.001933349,0.00004379415,0.00001982426,0.00001781623,0.0001724145,0.00002225471,0.000617074],"genre_scores_gemma":[0.9963629,0.0003295932,0.001789685,0.00003324728,0.000005931286,0.00001742863,0.0002781327,0.00000740396,0.001175739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009180151,"threshold_uncertainty_score":0.00307101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003320695560606591,"score_gpt":0.1837284673258881,"score_spread":0.1804077717652815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}