{"id":"W2001182111","doi":"10.1002/syn.20287","title":"Antipsychotic pathway genes with expression altered in opposite direction by antipsychotics and amphetamine","year":2006,"lang":"en","type":"article","venue":"Synapse","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Amphetamine; Haloperidol; Clozapine; Antipsychotic; Gene; Amisulpride; Striatum; Schizophrenia (object-oriented programming); Pharmacology; Biology; Medicine; Dopamine; Genetics; Neuroscience; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008982896,0.0001298899,0.0001102873,0.00005037044,0.00005449987,0.00002438501,0.00004653399,0.00009681184,0.000006841641],"category_scores_gemma":[0.000005817116,0.0001099041,0.00002220448,0.00009078479,0.0000514379,0.000006478841,0.00001993772,0.00004940491,0.000001400167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006857364,"about_ca_system_score_gemma":0.00001261751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002525843,"about_ca_topic_score_gemma":0.00005044834,"domain_scores_codex":[0.9992498,0.00005043253,0.0001551763,0.0002964861,0.00008588669,0.0001622667],"domain_scores_gemma":[0.9996868,0.000004757131,0.00006351252,0.0001721496,0.00002822819,0.00004449262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002129252,0.00007727186,0.01041065,0.00001728891,0.000006427131,0.00000507819,0.000007825191,0.0001079096,0.9864635,0.00001971687,0.0003838361,0.002287537],"study_design_scores_gemma":[0.001207367,0.0001721742,0.02308709,0.00006997387,0.000006721159,0.00003426108,0.00001196663,0.0002998149,0.9687032,0.00005924311,0.006142792,0.0002054523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910408,0.003275377,0.00517677,0.00006055065,0.00005358402,0.0001820254,0.00001264261,0.00001563389,0.0001826253],"genre_scores_gemma":[0.9983239,0.0001862399,0.00079815,0.00004833419,0.0001016718,0.00001373299,0.0001797276,0.00001754819,0.0003307545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01776038,"threshold_uncertainty_score":0.4481759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004215471699539411,"score_gpt":0.2048547720540581,"score_spread":0.2006393003545187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}