{"id":"W2001204983","doi":"10.1021/ja0498540","title":"Mispair-Aligned N<sup>3</sup>T-alkyl-N<sup>3</sup>T Interstrand Cross-Linked DNA:  Synthesis and Characterization of Duplexes with Interstrand Cross-Links of Variable Lengths","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Duplex (building); Base pair; Oligonucleotide; Alkyl; Circular dichroism; Stereochemistry; DNA; Crystallography; Cross-link; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003380881,0.0003107426,0.0006633999,0.00002241422,0.0000970477,0.0000534241,0.0005498672,0.0003084873,0.00002424892],"category_scores_gemma":[0.0001824518,0.0002205866,0.0004826356,0.0002205096,0.001671158,0.00003466877,0.0001691369,0.0003707579,2.971327e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006731278,"about_ca_system_score_gemma":0.0001785361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003160619,"about_ca_topic_score_gemma":3.427699e-7,"domain_scores_codex":[0.9981724,0.00004858891,0.0007674398,0.000333548,0.000354453,0.000323577],"domain_scores_gemma":[0.9979759,0.00007719149,0.001080227,0.0003839379,0.0003222792,0.0001604202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001046804,0.0002120443,0.007110898,0.0001650633,0.0005101308,0.0000020652,0.0006347189,0.0005223174,0.9893095,0.000004289227,0.0001110055,0.0003710848],"study_design_scores_gemma":[0.001927917,0.0003637273,0.002160509,0.0002606555,0.0001839622,0.0001237498,0.0007424171,0.0001908383,0.9934337,0.00003687047,0.0003272404,0.0002484721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983341,0.0001143822,0.0008746575,0.0003614656,0.00003132876,0.000118495,0.00009101391,0.000007907338,0.00006662557],"genre_scores_gemma":[0.9967875,0.0003091184,0.002293999,0.0002593503,0.0002163154,0.000004345594,0.00002131167,0.00004028088,0.00006772154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004950389,"threshold_uncertainty_score":0.8995259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004863770896826007,"score_gpt":0.2274733694832377,"score_spread":0.2226095985864117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}