{"id":"W2001204983","doi":"10.1021/ja0498540","title":"Mispair-Aligned N<sup>3</sup>T-alkyl-N<sup>3</sup>T Interstrand Cross-Linked DNA:  Synthesis and Characterization of Duplexes with Interstrand Cross-Links of Variable Lengths","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Duplex (building); Base pair; Oligonucleotide; Alkyl; Circular dichroism; Stereochemistry; DNA; Crystallography; Cross-link; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014247,0.0001859534,0.0001200575,0.0001114133,0.0000662182,0.0001413351,0.0001237843,0.0002348123,0.0006054112],"category_scores_gemma":[0.0002656281,0.00009548463,0.00009133839,0.0001121376,0.0001129932,0.0001831599,0.00006514964,0.0002140997,0.0001664192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409956,"about_ca_system_score_gemma":0.0001065145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071303,"about_ca_topic_score_gemma":0.0005004914,"domain_scores_codex":[0.9998931,0.0000196312,0.00001047277,0.0000336099,0.00003159195,0.00001159741],"domain_scores_gemma":[0.9998259,0.00003120783,0.00007142053,0.00001177811,0.00003069955,0.00002897804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004020032,0.000006655774,0.0001412414,0.00001452538,0.000003054769,0.00001226961,0.000008822397,0.00007998389,0.9990516,0.00002984482,0.000008269416,0.000603445],"study_design_scores_gemma":[0.000002803379,0.0002038514,0.001217713,0.000001290052,0.000007651191,0.0001321627,0.000006589804,0.0006545613,0.997244,0.0000153163,0.0005118686,0.000002182816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935868,0.000645549,0.005125909,0.00001757026,0.000009299918,0.00002677022,0.0001672167,0.00003559828,0.000385183],"genre_scores_gemma":[0.9878726,0.0004212983,0.009641186,0.00004227087,0.000004169511,0.00003565255,0.0006005965,0.00002135776,0.001360919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006054112,"threshold_uncertainty_score":0.002025306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004863770896826007,"score_gpt":0.2274733694832377,"score_spread":0.2226095985864117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}