{"id":"W2001209876","doi":"10.1038/pcan.2012.16","title":"Metformin enhances the antiproliferative and apoptotic effect of bicalutamide in prostate cancer","year":2012,"lang":"en","type":"article","venue":"Prostate Cancer and Prostatic Diseases","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; McGill University; Health Sciences Centre; Institute for Clinical Evaluative Sciences; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Health Canada; National Institutes of Health; Prostate Cancer Canada","keywords":"Bicalutamide; LNCaP; Prostate cancer; Metformin; Medicine; Cell growth; Cancer research; Endocrinology; DU145; Internal medicine; In vivo; Cell cycle; Apoptosis; Clonogenic assay; Androgen receptor; Cancer; Pharmacology; Biology; Diabetes mellitus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003597231,0.0002764066,0.0003933268,0.00005424202,0.0001015119,0.00004437778,0.0001036437,0.00005094043,0.0000299689],"category_scores_gemma":[0.0001213056,0.0001726774,0.00005718807,0.0001715472,0.0003916066,0.00004075785,0.0000919064,0.00009804907,7.78369e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001739862,"about_ca_system_score_gemma":0.0001362377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001672584,"about_ca_topic_score_gemma":0.00008537047,"domain_scores_codex":[0.9984894,0.0001770376,0.0003208171,0.0003497771,0.0001847606,0.0004781589],"domain_scores_gemma":[0.9992891,0.00009991471,0.0001597889,0.0001950307,0.00007265914,0.0001835215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001521354,0.0001336774,0.550752,0.001523216,0.0002218131,0.000002155251,0.003318177,0.00004145541,0.02404427,0.0001175185,0.0004234318,0.4179009],"study_design_scores_gemma":[0.005070308,0.001195852,0.1729695,0.0005948549,0.0006729158,0.000009352083,0.001136748,0.0001838963,0.785273,0.0008258242,0.0310998,0.0009679455],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6107401,0.3880353,0.000003422633,0.00005188178,0.0001225988,0.0006990935,0.0003178108,0.000005314065,0.00002451179],"genre_scores_gemma":[0.8132548,0.1851768,0.00002758077,0.0002367136,0.0001282424,0.0009915569,0.0000420642,0.00002308644,0.0001191801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7612287,"threshold_uncertainty_score":0.7041579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005760686546217126,"score_gpt":0.2776471420424563,"score_spread":0.2718864554962391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}