{"id":"W2001230722","doi":"10.1016/j.bbrc.2008.12.179","title":"CD40 ligation converts TGF-β-secreting tolerogenic CD4−8− dendritic cells into IL-12-secreting immunogenic ones","year":2009,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"CD40; Ligation; CTL*; Immune system; Cytotoxic T cell; Immunotherapy; Immunology; CD8; Dendritic cell; Cancer immunotherapy; Immune tolerance; Biology; Cancer research; In vitro; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001569741,0.0004902801,0.0002563068,0.0003587428,0.0001935508,0.0007372266,0.0001990779,0.0003342783,0.002883359],"category_scores_gemma":[0.0001524065,0.0002254939,0.0003662671,0.0002460855,0.0002031595,0.0002924527,0.0003157847,0.00135196,0.001260491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638577,"about_ca_system_score_gemma":0.0002703668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002720469,"about_ca_topic_score_gemma":0.0002785061,"domain_scores_codex":[0.999707,0.00002722672,0.00002604094,0.00004247639,0.0000515436,0.000145523],"domain_scores_gemma":[0.9997652,0.00004408686,0.00004520472,0.00003832511,0.00002459135,0.00008270963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001442621,0.00003818127,0.0001446631,0.00001744071,0.000002792438,0.00006155863,0.00001654857,0.00002889496,0.9984847,0.0001109526,0.00003013815,0.0009199238],"study_design_scores_gemma":[0.00002889733,0.0001020209,0.0009625755,0.000003688227,0.00001106822,0.0001741164,0.00003286034,0.0002505238,0.9965271,0.0000736341,0.001830522,0.000003117658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941742,0.0004570399,0.002419908,0.00008349427,0.0001204725,0.0000377712,0.0003087411,0.0001184081,0.002279925],"genre_scores_gemma":[0.9934506,0.0004629074,0.002146521,0.00007362279,0.00004310735,0.00003641382,0.0005447299,0.00007223502,0.003169743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002883359,"threshold_uncertainty_score":0.00964576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04194316835131883,"score_gpt":0.3299450480128747,"score_spread":0.2880018796615558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}