{"id":"W2001273171","doi":"10.1002/mabi.200900387","title":"Chemical Modification of Hydrophobic Block in Poly(Ethylene Oxide) Poly(Caprolactone) Based Nanocarriers: Effect on the Solubilization and Hemolytic Activity of Amphotericin B","year":2010,"lang":"en","type":"article","venue":"Macromolecular Bioscience","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Institute","keywords":"Nanocarriers; Caprolactone; Ethylene oxide; Chemistry; Chemical modification; Poly ethylene; Polymer chemistry; Block (permutation group theory); Amphotericin B; Oxide; Drug carrier; Chemical engineering; Organic chemistry; Ethylene; Antifungal; Drug delivery; Copolymer; Polymer; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394949,0.000252162,0.0001412538,0.00009117949,0.00007390761,0.0001795497,0.0001240504,0.0002871274,0.0005215731],"category_scores_gemma":[0.0002625428,0.0001220394,0.0001508512,0.00007562392,0.0001671571,0.0002728769,0.0001284732,0.0002362408,0.0002666637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001337818,"about_ca_system_score_gemma":0.0001184362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001908683,"about_ca_topic_score_gemma":0.0002476788,"domain_scores_codex":[0.9998871,0.00002251075,0.00001313374,0.00002549008,0.00003122243,0.00002054089],"domain_scores_gemma":[0.9998401,0.00003861128,0.00006795162,0.00001370691,0.00002001519,0.00001960344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003073673,0.000009969985,0.00002872787,0.00002092456,0.000001843298,0.00002060263,0.000003805648,0.00005364165,0.9992532,0.00001988862,0.000003782592,0.0005529423],"study_design_scores_gemma":[0.000007349697,0.0001356278,0.0004317838,0.000001882056,0.000007843142,0.00008230961,0.000003008757,0.000265181,0.9985819,0.000008056443,0.0004726075,0.000002357476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954509,0.001044794,0.002786341,0.00005343377,0.00001616856,0.00001961527,0.00003470171,0.00002736385,0.000566609],"genre_scores_gemma":[0.9943979,0.0008896764,0.003492308,0.00005307993,0.00001394683,0.00002303728,0.0000595196,0.00001346032,0.001056895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005215731,"threshold_uncertainty_score":0.001744807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008145864863959917,"score_gpt":0.2302549447451404,"score_spread":0.2221090798811805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}