{"id":"W2001273171","doi":"10.1002/mabi.200900387","title":"Chemical Modification of Hydrophobic Block in Poly(Ethylene Oxide) Poly(Caprolactone) Based Nanocarriers: Effect on the Solubilization and Hemolytic Activity of Amphotericin B","year":2010,"lang":"en","type":"article","venue":"Macromolecular Bioscience","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Cancer Research Institute","keywords":"Nanocarriers; Caprolactone; Ethylene oxide; Chemistry; Chemical modification; Poly ethylene; Polymer chemistry; Block (permutation group theory); Amphotericin B; Oxide; Drug carrier; Chemical engineering; Organic chemistry; Ethylene; Antifungal; Drug delivery; Copolymer; Polymer; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238393,0.0001937963,0.0002664036,0.0001500499,0.00008300482,0.00004410357,0.0004332981,0.0001075924,0.00002024863],"category_scores_gemma":[0.0004126011,0.0001475875,0.00005852785,0.000737393,0.0007659839,0.0001313198,0.0001007778,0.0001702228,0.000007182649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005307081,"about_ca_system_score_gemma":0.0001286623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003759629,"about_ca_topic_score_gemma":0.00001624338,"domain_scores_codex":[0.9980787,0.0002280087,0.0003277166,0.0005222275,0.0005141883,0.0003291541],"domain_scores_gemma":[0.9986724,0.0002628505,0.0002455421,0.0006537703,0.0000709555,0.0000944543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001593075,0.0001553801,0.0005579905,0.00004640915,0.000001409041,0.000004657299,0.00009453099,0.00006855615,0.9983382,0.00006649818,8.532097e-7,0.0005061965],"study_design_scores_gemma":[0.0005787577,0.0002182214,0.002209291,0.0000537471,0.00001280035,0.000006765018,0.00001112366,0.02148084,0.9752477,0.00003561539,0.000001584173,0.0001435547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985461,0.00005490242,0.0005605944,0.0002385772,0.0001176488,0.0004253224,0.00001482035,0.00002420293,0.00001787623],"genre_scores_gemma":[0.9992445,0.000001976124,0.000584657,0.0001191998,0.000007241226,0.00002290393,0.000001665817,0.00001478115,0.000003103986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02309051,"threshold_uncertainty_score":0.6018445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008145864863959917,"score_gpt":0.2302549447451404,"score_spread":0.2221090798811805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}