{"id":"W2001283352","doi":"10.1002/cbic.200500114","title":"Two Nucleophilic Mutants of the <i>Micromonospora viridifaciens</i> Sialidase Operate with Retention of Configuration by Two Different Mechanisms","year":2005,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada","keywords":"Mutant; Nucleophile; Stereochemistry; Chemistry; Walden inversion; Active site; Sialidase; Enzyme; Amino acid; Biochemistry; Catalysis; Neuraminidase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608765,0.0001664582,0.0002243477,0.0000240409,0.0000872758,0.00003118273,0.0002072903,0.00006127476,0.0002521004],"category_scores_gemma":[0.00001670871,0.000104583,0.00006451523,0.0001509835,0.0001382622,0.0001470634,0.00004352009,0.00007862261,0.00001214701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003990768,"about_ca_system_score_gemma":0.00002996777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003503194,"about_ca_topic_score_gemma":0.00001550907,"domain_scores_codex":[0.9989035,0.00004496564,0.000322245,0.0002774045,0.0002728633,0.0001790171],"domain_scores_gemma":[0.9991517,0.00001316613,0.0002961135,0.000359446,0.0001319086,0.00004763997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008032793,0.0000567553,0.00003259366,0.0000244222,0.000008459317,3.247534e-7,0.0002041166,0.00002819952,0.9982591,0.0007622191,0.0002115583,0.0003319366],"study_design_scores_gemma":[0.001000727,0.00009906066,0.0002364674,0.00004518976,0.00004061098,0.000009621266,0.0001041071,0.00009166935,0.9979448,0.0002236007,0.00007696603,0.0001272093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973754,0.00004970015,0.001140424,0.0001379651,0.0002126793,0.0002478243,0.0000677494,0.00002869031,0.000739514],"genre_scores_gemma":[0.9990931,0.000005607714,0.0004662691,0.0001033914,0.0000647254,0.000007726935,0.00003423364,0.00001550045,0.0002094993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001717593,"threshold_uncertainty_score":0.4264773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006519275254907625,"score_gpt":0.2066509964151351,"score_spread":0.2001317211602275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}