{"id":"W2001294340","doi":"10.1073/pnas.1216011110","title":"Characterization of pathogenic human monoclonal autoantibodies against GM-CSF","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"","keywords":"Autoantibody; Immunology; Epitope; Pulmonary alveolar proteinosis; Monoclonal; Monoclonal antibody; Autoimmunity; Medicine; Biology; Antibody; Lung; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709844,0.0002635907,0.0001690656,0.000404552,0.0001835648,0.000260973,0.0001604389,0.000284942,0.0007498869],"category_scores_gemma":[0.000689105,0.00008889212,0.0002263118,0.000168663,0.0001463037,0.0001119446,0.0001572621,0.0002468016,0.0002966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002624684,"about_ca_system_score_gemma":0.000127819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008523831,"about_ca_topic_score_gemma":0.0006189708,"domain_scores_codex":[0.9998521,0.00002871363,0.00001581253,0.00002628736,0.00004122564,0.00003579656],"domain_scores_gemma":[0.9996245,0.0001246958,0.00003751631,0.00004410593,0.00009786803,0.00007127905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001801585,0.00006532075,0.02400028,0.00005840469,0.00002099229,0.001455358,0.000149838,0.000166201,0.9622954,0.0002394071,0.0002241376,0.01114466],"study_design_scores_gemma":[0.0002497106,0.002020816,0.2387404,0.0001315684,0.0002086908,0.03968183,0.0004539481,0.00698692,0.6766921,0.00100309,0.03378951,0.00004143227],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963871,0.0007927017,0.001369814,0.00005364278,0.00001881865,0.00002522983,0.0001241775,0.00002445503,0.001204044],"genre_scores_gemma":[0.9973808,0.0002538242,0.001488327,0.00007700797,0.00001781977,0.00001587264,0.0004236733,0.000008234968,0.0003344761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008523831,"threshold_uncertainty_score":0.00250864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02231504058529901,"score_gpt":0.2632706333014821,"score_spread":0.2409555927161831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}