{"id":"W2001295759","doi":"10.1016/j.bbrc.2009.02.013","title":"microRNA-221 regulates high glucose-induced endothelial dysfunction","year":2009,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Macdonald Stewart Foundation; American Heart Association; U.S. Department of Defense","keywords":"Umbilical vein; microRNA; Endothelial dysfunction; Endothelial stem cell; Diabetes mellitus; Receptor; Cell; Human umbilical vein endothelial cell; Endocrinology; Internal medicine; Biology; Cell biology; Chemistry; Medicine; Biochemistry; Gene; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003039734,0.0001684861,0.0001527152,0.00008012076,0.0003568158,0.00007660632,0.0005648477,0.0002119081,0.00001424599],"category_scores_gemma":[0.000311935,0.0001530777,0.00009585285,0.0003004334,0.0004586487,0.00001110687,0.0003615364,0.0003103597,0.00003976053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004430119,"about_ca_system_score_gemma":0.00008736275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003938637,"about_ca_topic_score_gemma":0.000004096189,"domain_scores_codex":[0.9984176,0.0002263886,0.0002320852,0.0004355121,0.0003083645,0.0003800597],"domain_scores_gemma":[0.9982244,0.0000870634,0.00005403552,0.001099424,0.0003028663,0.0002321582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227076,0.0003265837,0.00002743323,0.000009127129,0.00002248193,4.83411e-7,0.00001046143,1.935999e-7,0.9860727,0.002188583,0.002312347,0.008906964],"study_design_scores_gemma":[0.0004736572,0.0003248684,0.0108041,0.00002509525,0.00001523503,0.000006087952,0.0000210612,0.0001433405,0.9764463,0.002760728,0.008790954,0.0001885699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941721,0.001112608,0.00007407517,0.003796465,0.00003021531,0.0002919289,0.00004046276,0.00003277151,0.0004493657],"genre_scores_gemma":[0.9969955,0.000674588,0.001165547,0.0001417154,0.0003210241,0.00003713859,0.0004423255,0.00001639559,0.0002057281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01077666,"threshold_uncertainty_score":0.6242328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04037416252719502,"score_gpt":0.3326182562971108,"score_spread":0.2922440937699158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}