{"id":"W2001304703","doi":"10.1016/j.pnpbp.2010.03.005","title":"Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: Relevance to depression","year":2010,"lang":"en","type":"review","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Stressor; Depression (economics); Corticosterone; Animal models of depression; Psychology; Animal model; Neuroscience; Animal studies; Glucocorticoid; Chronic stress; Preclinical research; Hormone; Clinical psychology; Medicine; Internal medicine; Antidepressant; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001832466,0.0006538245,0.001733895,0.0003913691,0.00009231443,0.00003800017,0.0006769079,0.001098513,0.00004654517],"category_scores_gemma":[0.0004158264,0.0004343606,0.0001857083,0.0007165292,0.001467826,0.0000799514,0.0003963415,0.00196962,0.000007487382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000013845,"about_ca_system_score_gemma":0.0001289483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002538824,"about_ca_topic_score_gemma":0.00001278786,"domain_scores_codex":[0.9947076,0.001422529,0.001243301,0.001769404,0.00017086,0.0006863196],"domain_scores_gemma":[0.9975277,0.001310561,0.0005597868,0.0003565611,0.00002684585,0.0002185568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002031872,0.000789003,0.3391798,0.001025386,0.000006411939,0.0002372887,0.00002304844,5.768608e-7,0.002773468,0.00009826518,0.00003091177,0.6538039],"study_design_scores_gemma":[0.01105734,0.01713007,0.568398,0.01023005,0.0005550319,0.002174194,0.00007770628,0.00003520585,0.0009576639,0.002567347,0.3827228,0.004094589],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4885259,0.5083491,3.090069e-7,0.000195977,0.001285047,0.001548682,0.00004462746,0.00003385411,0.00001648702],"genre_scores_gemma":[0.1953697,0.8028448,0.000160895,0.000797855,0.00008400742,0.000702722,0.000005386935,0.00002564042,0.000008976348],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6497093,"threshold_uncertainty_score":0.9998108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06488677707347211,"score_gpt":0.3976878946597712,"score_spread":0.332801117586299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}